Shefner S A, Chiu T H
Brain Res. 1986 Feb 26;366(1-2):364-8. doi: 10.1016/0006-8993(86)91320-x.
Intracellular recording was used to study the effect of adenosine (3-100 microM) on rat locus coeruleus (LC) neurons in a brain slice preparation. Bath application of adenosine (100 microM) reduced the rate of spontaneous firing in 88% of LC neurons. In some LC neurons adenosine also caused membrane hyperpolarization (2-10 mV) and reductions in input resistance of 9-24%. Adenosine effects were dose-dependent and antagonized by the adenosine receptor antagonist theophylline.
采用细胞内记录技术，在脑片标本中研究了腺苷（3 - 100微摩尔）对大鼠蓝斑（LC）神经元的影响。浴槽中应用腺苷（100微摩尔）可使88%的LC神经元自发放电频率降低。在一些LC神经元中，腺苷还可引起膜超极化（2 - 10毫伏），并使输入电阻降低9 - 24%。腺苷的作用呈剂量依赖性，并被腺苷受体拮抗剂茶碱所拮抗。
