Baumeister A A, Frye G D
Brain Res. 1986 Mar 26;369(1-2):231-42. doi: 10.1016/0006-8993(86)90532-9.
Bilateral microinjection of muscimol (60 ng), a gamma-aminobutyric acid (GABA) agonist, into the central region of the substantia nigra (pars reticulata) produced self-injurious behavior (SIB), stereotyped behavior and analgesic-like effects in rats. Bilateral electrolytic lesions of the midbrain reticular formation ventrolateral to the periaqueductal gray matter completely blocked the SIB but had little effect on stereotyped behavior produced by intranigral muscimol. Lesions of the midbrain reticular formation reduced the antinociceptive effect of intranigral muscimol on the tail-flick but not on the hot-plate test. Bilateral microinjection of muscimol (10-100 ng) into the midbrain reticular formation produced intense stereotyped behavior and had an analgesic-like effect on the hot-plate test but not on the tail-flick test. Stereotyped behavior appeared to interfere with the paw-lick response on the hot-plate test. These data suggest that the antinociceptive effect of intranigral muscimol on the tail-flick test is mediated by fibers that project to or pass through the midbrain reticular formation and that analgesia may play an important role in muscimol-induced SIB. The midbrain reticular formation does not appear to be involved in the stereotyped behavior produced by intranigral muscimol.
向大鼠黑质网状部中央区域双侧微量注射γ-氨基丁酸（GABA）激动剂蝇蕈醇（60纳克）会产生自伤行为（SIB）、刻板行为和类镇痛效应。导水管周围灰质腹外侧的中脑网状结构双侧电解损伤完全阻断了自伤行为，但对黑质内注射蝇蕈醇所产生的刻板行为影响不大。中脑网状结构损伤降低了黑质内注射蝇蕈醇对甩尾试验的抗伤害感受作用，但对热板试验无影响。向中脑网状结构双侧微量注射蝇蕈醇（10 - 100纳克）会产生强烈的刻板行为，且对热板试验有类镇痛效应，但对甩尾试验无影响。刻板行为似乎会干扰热板试验中的舔爪反应。这些数据表明，黑质内注射蝇蕈醇对甩尾试验的抗伤害感受作用是由投射到或穿过中脑网状结构的纤维介导的，并且镇痛可能在蝇蕈醇诱导的自伤行为中起重要作用。中脑网状结构似乎不参与黑质内注射蝇蕈醇所产生的刻板行为。
