Malignant fibrous histiocytoma of soft tissue. Correlation between clinical variables and histologic malignancy grade.

The prognosis for malignant fibrous histiocytoma (MFH) of soft tissue is correlated to histologic malignancy grade but also has been related to tumor size, depth, and location. In a consecutive series of 61 patients with MFH we found that large, deep-seated and thigh tumors were more often highly malignant histologically. This finding suggests that the prognostic significance which has been attributed to the clinical variables may be a function of their covariation with histologic malignancy grade.