Palmer G C, Jones D J, Medina M A, Palmer S J, Stavinoha W B
Pharmacology. 1978;17(5):280-7. doi: 10.1159/000136866.
The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both agents blocked dopamine-sensitive adenylate cyclase to a greater degree than the NE-responsive enzyme. Again CPZ was more potent than haloperidol. Acute injections (1/2--8h) of the neuroleptics usually resulted in lower steady state levels of pulmonary cyclic AMP and cyclic GMP following rapid (0.5 sec) tissue inactivation by microwave irradiation. On a subchronic injection schedule, the in vivo levels of pulmonary cyclic AMP tended to increase.
去甲肾上腺素（NE）诱导的小鼠肺组织切片中环状AMP的积累受到氯丙嗪（CPZ）的抑制，氟哌啶醇的抑制作用较小。在肺微粒体部分，这两种药物对多巴胺敏感的腺苷酸环化酶的阻断作用比对NE反应性酶的阻断作用更大。同样，CPZ比氟哌啶醇更有效。急性注射（1/2 - 8小时）这些抗精神病药物后，经微波照射使组织快速（0.5秒）失活，通常会导致肺中环状AMP和环状GMP的稳态水平降低。在亚慢性注射方案中，肺中环状AMP的体内水平趋于升高。
