Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India; Postgraduate and Research Department of Biochemistry, Government Arts College For Women, Krishnagiri, 635 002, Tamilnadu, India.
Biomed Pharmacother. 2018 Nov;107:292-302. doi: 10.1016/j.biopha.2018.07.162. Epub 2018 Aug 8.
Therapeutic approaches based on dietary compounds obtained from food products to handle diabetes involving oxidative stress and inflammation. Garlic is a common spice and has a long history as a folk remedy. Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases. Herein, we investigated the potential role of AMS in ameliorating the effects of oxidative stress and inflammation in the liver of streptozotocin (STZ)-induced experimental rats. Diabetes was induced by single intraperitoneal (i.p.) injection of STZ (40 mg/kg/b.w). STZ-induced hyperglycemic rats received daily intragastric doses of 50, 100 and 200 mg/kg/b.w of the AMS for 30 days. Dietary intervention of AMS (100 mg/kg b.w) resulted in significant attenuation in blood glucose and expression of pro-inflammatory markers TNF-α, IL-6, NF-κB p65 unit and significant elevation in the plasma insulin level. Moreover, AMS instigated a marked enhance in the levels of hepatic tissue non enzymatic antioxidants and the activities enzymatic antioxidants of diabetic rats with significant decline in lipid peroxides and hydroperoxides formation, serum biomarkers of liver damage, thus representing the protecting efficacy of AMS in hyperglycemic state. The pathological abnormalities in hepatic tissues of diabetic rats were significantly ameliorated by AMS supplementation and offered great support to the biochemical findings. These conclusions explicate the prospective use of AMS as a promising compound against glucotoxicity mediated hepatic oxidative dysfunction in rats. Clinical trials in validating this benefit for optimizing the AMS nutrition are however warranted.
基于从食品中获得的膳食化合物的治疗方法来处理涉及氧化应激和炎症的糖尿病。大蒜是一种常见的香料，作为民间疗法已有很长的历史。烯丙基甲基硫醚（AMS）是一种潜在的大蒜衍生的有机硫化合物，在各种疾病中显示出广泛的积极作用。在此，我们研究了 AMS 在改善链脲佐菌素（STZ）诱导的实验大鼠肝脏氧化应激和炎症作用中的潜在作用。糖尿病通过单次腹腔（i.p.）注射 STZ（40mg/kg/b.w）诱导。STZ 诱导的高血糖大鼠每天接受 50、100 和 200mg/kg/b.w 的 AMS 胃内剂量 30 天。AMS（100mg/kg b.w）的饮食干预导致血糖显著降低，促炎标志物 TNF-α、IL-6、NF-κB p65 单位的表达降低，血浆胰岛素水平显著升高。此外，AMS 可显著提高糖尿病大鼠肝组织非酶抗氧化剂水平和酶抗氧化剂活性，显著降低脂质过氧化物和氢过氧化物的形成，血清肝损伤标志物，从而代表 AMS 在高血糖状态下的保护效力。AMS 补充可显著改善糖尿病大鼠肝组织的病理异常，并为生化发现提供有力支持。这些结论阐明了 AMS 作为一种有前途的化合物用于对抗大鼠糖毒性介导的肝氧化功能障碍的潜在用途。然而，需要进行临床试验来验证这种益处，以优化 AMS 的营养。
