Department of Surgery, Stanford University School of Medicine, 291 campus Drive, Stanford, CA 94305-5101, USA.
Neuroendocrine Tumor Centra, Fukuoka Sanno Hospital, International University of Health and Welfare, 3-6-45 Momochihama, Sawara-Ku, Fukuoka 814-0001, Japan.
Endocrinol Metab Clin North Am. 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009.
This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial.
本文回顾了由于胃泌素分泌性神经内分泌肿瘤（胃泌素瘤）导致的 Zollinger-Ellison 综合征（ZES）患者的手术和内科治疗作用。它集中讨论了目前的现状，但也简要回顾了治疗方法随时间的变化。一般来说，目前手术和内科治疗是互补的；然而，在某些情况下，如 ZES 和多发性内分泌肿瘤 1 型患者，治疗方法仍存在争议。
