Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
Endocrinol Metab Clin North Am. 2018 Sep;47(3):627-643. doi: 10.1016/j.ecl.2018.04.001. Epub 2018 Jul 11.
Surgical approaches to hepatic metastases occupy an important role in the management of patients with neuroendocrine neoplasms and may have curative or palliative intentions. Resection of hepatic disease with curative intent is the only modality offering potential cure for patients with liver metastases; however, only a minority of patients are eligible. Regardless of resection margin, disease recurrence almost invariably occurs and novel adjuvant/neoadjuvant therapies are mandated to be included within multimodal treatment concepts. Liver transplantation in meticulously selected patients may be associated with excellent outcomes, but unfortunately demands on donated organs limit the wider utilization of this approach.
手术方法在神经内分泌肿瘤患者肝转移的治疗中占有重要地位，其目的可能是治愈或姑息。有治愈意图的肝切除术是唯一能为肝转移患者提供潜在治愈机会的方法；然而，只有少数患者符合条件。无论切缘如何，疾病几乎总是会复发，因此需要将新的辅助/新辅助治疗纳入多模式治疗方案中。精心选择患者的肝移植可能会带来极好的结果，但不幸的是，供体器官的需求限制了这种方法的广泛应用。
