Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Centre for affective Disorders, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK.
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Apr 20;91:28-37. doi: 10.1016/j.pnpbp.2018.08.004. Epub 2018 Aug 9.
Major depressive disorders are common conditions with relatively limited response to treatment. In order to improve response to treatment, a better understanding of functional neuroanatomy is necessary to improve treatment targets at brain level. This work summarises the literature of longitudinal functional magnetic resonance imaging studies in major depression to identify brain regions where aberrant neural activity normalises after clinical response following treatment with pharmacological compounds with known antidepressant properties. Hyperactivity in regions such as the amygdala and the ventral components of the anterior cingulate cortex were some of the most replicated findings of functional MRI studies in major depression and normalisation of aberrant activity one of the best predictive biomarkers of treatment response.
重度抑郁症是常见的疾病，对治疗的反应相对有限。为了提高治疗反应，需要更好地了解功能神经解剖学，以改善大脑水平的治疗靶点。这项工作总结了重度抑郁症纵向功能磁共振成像研究的文献，以确定在使用具有已知抗抑郁特性的药物化合物治疗后，临床反应后神经活动正常化的脑区。杏仁核和前扣带皮层腹侧成分等区域的过度活跃是重度抑郁症功能磁共振成像研究中最常见的发现之一，而异常活动的正常化是治疗反应的最佳预测生物标志物之一。
