Haroon Muhammad, Khan Kamil, Thong Lorraine, Ali Kabir, Janjua Fayyaz
Division of Rheumatology, Department of Medicine, University Hospital Kerry, Tralee, Ireland.
Division of Rheumatology, Department of Medicine, Pakistan Kidney and Liver Institute, Lahore, Pakistan.
Ir J Med Sci. 2019 May;188(2):531-536. doi: 10.1007/s11845-018-1882-2. Epub 2018 Aug 11.
(1) To calculate the absolute fracture risk by using the fracture risk assessment (FRAX) model among elderly medical inpatients; (2) to assess the risk of falls, especially among patients with increased risk of fractures; and (3) to design and implement a bone health protocol to improve the assessment of fracture risk.
The study participants were all inpatients admitted to the medical wards at University Hospital Kerry, Ireland. All consecutive eligible patients aged ≥ 65 years were prospectively evaluated to populate clinical risk factor variables used in the FRAX model and the fall assessment was made by using Fracture Risk Questionnaire.
Consecutive 465 medical inpatients were screened, and 200 eligible medical inpatients were evaluated. The mean age of the cohort was 73.8 ± 9 years and 56% were male. The body mass index of the cohort was 27 ± 5, and only 21% (n = 42) of patients reported having ever had a DXA scan. Previous personal history of low fragility fracture was present in 20.5% (n = 41) of the patients. The absolute 10-year risk of major osteoporotic and hip fracture was 15 ± 12 and 7.6 ± 11, respectively, and 25.5% (n = 51) and 64.5% (n = 129) respectively of the cohort had fracture risks exceeding the National Osteoporosis Federation (NOF) thresholds for treatment. High fall risk was noted in 63% of the cohort.
A very high prevalence of fracture and fall risk was noted. A medical inpatient stay offers a window of opportunity for assessment of osteoporotic fracture risk. With these findings, a bone health protocol has been developed.
(1)使用骨折风险评估(FRAX)模型计算老年内科住院患者的绝对骨折风险;(2)评估跌倒风险,尤其是骨折风险增加的患者;(3)设计并实施一项骨骼健康方案,以改善骨折风险评估。
研究参与者为爱尔兰克里大学医院内科病房的所有住院患者。对所有年龄≥65岁的连续符合条件的患者进行前瞻性评估,以填写FRAX模型中使用的临床风险因素变量,并使用骨折风险问卷进行跌倒评估。
连续筛查了465名内科住院患者,对200名符合条件的内科住院患者进行了评估。该队列的平均年龄为73.8±9岁,56%为男性。该队列的体重指数为27±5,只有21%(n=42)的患者报告曾进行过双能X线吸收法(DXA)扫描。20.5%(n=41)的患者有既往低脆性骨折个人史。主要骨质疏松性骨折和髋部骨折的绝对10年风险分别为15±12和7.6±11,该队列中分别有25.5%(n=51)和64.5%(n=129)的患者骨折风险超过国家骨质疏松症联合会(NOF)治疗阈值。63%的队列有高跌倒风险。
注意到骨折和跌倒风险的患病率非常高。内科住院为评估骨质疏松性骨折风险提供了一个机会窗口。基于这些发现,已制定了一项骨骼健康方案。