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大鼠脑、豚鼠小脑及神经母细胞瘤x胶质瘤（NG 108-15）中抗独特型抗阿片受体抗体的亚类特异性

Subclass specificity of anti-idiotypic anti-opiate receptor antibodies in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15).

作者信息

Myers W E, Glasel J A

出版信息

Life Sci. 1986 May 12;38(19):1783-8. doi: 10.1016/0024-3205(86)90129-3.

DOI:10.1016/0024-3205(86)90129-3
PMID:3010023
Abstract

Receptor subclass recognition properties of affinity-purified rabbit polyclonal anti-idiotypic anti-opiate receptor antibodies in various membrane preparations have been determined. The anti-receptor immunoglobulins significantly decrease binding of 3H-[D-Ala2,-MePhe4,Gly-ol5]enkephalin, a highly selective mu agonist, in rat neural membrane. In the presence of a concentration of the unlabeled ligand sufficient to block existing mu sites, the antibodies compete, to a lesser degree with 3H-[D-Ala2,D-Leu5]enkephalin for delta site occupancy in both rat neural membrane, and neuroblastoma x glioma membrane preparations. The antibodies do not displace 3H-ethylketocyclazocine from rat brain or guinea pig cerebellum.

摘要

已测定亲和纯化的兔抗独特型抗阿片受体抗体在各种膜制剂中的受体亚类识别特性。抗受体免疫球蛋白显著降低了大鼠神经膜中高选择性μ激动剂3H-[D-丙氨酸2，-甲基苯丙氨酸4，甘氨酸-醇5]脑啡肽的结合。在存在足以阻断现有μ位点的未标记配体浓度的情况下，这些抗体在大鼠神经膜和神经母细胞瘤x胶质瘤膜制剂中与3H-[D-丙氨酸2，D-亮氨酸5]脑啡肽竞争占据δ位点，但程度较小。这些抗体不会从大鼠脑或豚鼠小脑中置换3H-乙基酮环唑辛。

相似文献

1
Subclass specificity of anti-idiotypic anti-opiate receptor antibodies in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15).大鼠脑、豚鼠小脑及神经母细胞瘤x胶质瘤（NG 108-15）中抗独特型抗阿片受体抗体的亚类特异性
Life Sci. 1986 May 12;38(19):1783-8. doi: 10.1016/0024-3205(86)90129-3.
2
Opioid binding to rat and guinea-pig neural membranes in the presence of physiological cations at 37 degrees C.在37摄氏度生理阳离子存在的情况下，阿片类药物与大鼠和豚鼠神经膜的结合。
J Pharmacol Exp Ther. 1985 Jun;233(3):722-8.
3
Temperature dependence of the binding of mu, delta and kappa agonists to the opiate receptors in guinea-pig brain.豚鼠脑内μ、δ和κ阿片受体激动剂结合的温度依赖性
Eur J Pharmacol. 1988 Feb 9;146(2-3):247-52. doi: 10.1016/0014-2999(88)90299-3.
4
Opioid ligand binding sites in the spinal cord of the guinea-pig.豚鼠脊髓中的阿片样物质配体结合位点
Neuropharmacology. 1986 May;25(5):471-80. doi: 10.1016/0028-3908(86)90170-x.
5
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.阿片受体激动剂结合的钠调节。I. 钠替代对7315c和NG108-15细胞及细胞膜中μ型和δ型受体结合的影响。
Mol Pharmacol. 1986 Aug;30(2):81-9.
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Kappa-opiate binding to rat brain and guinea pig cerebellum: sensitivity towards ions and nucleotides.κ-阿片受体与大鼠脑和豚鼠小脑的结合：对离子和核苷酸的敏感性
Neurosci Lett. 1986 Feb 14;64(1):81-4. doi: 10.1016/0304-3940(86)90667-1.
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Characterization of opioid binding sites in murine neuroblastoma.
Brain Res. 1988 May 24;449(1-2):80-8. doi: 10.1016/0006-8993(88)91026-8.
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Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.兔中枢神经系统中的多个阿片类结合位点。小脑内μ亚型占主导，丘脑内κ亚型的特征描述。
Mol Pharmacol. 1983 Jul;24(1):23-9.
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Differential ontogeny of multiple opioid receptors (mu, delta, and kappa).多种阿片受体（μ、δ和κ）的差异个体发生
J Neurosci. 1985 Mar;5(3):584-8. doi: 10.1523/JNEUROSCI.05-03-00584.1985.
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Traumatic injury alters opiate receptor binding in rat spinal cord.
Ann Neurol. 1986 May;19(5):498-501. doi: 10.1002/ana.410190514.

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