解偶联蛋白2基因Ala55val多态性与突发性感音神经性听力损失之间的关联
Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss.
作者信息
Koide Yusuke, Teranishi Masaaki, Sugiura Saiko, Uchida Yasue, Nishio Naoki, Kato Ken, Otake Hironao, Yoshida Tadao, Otsuka Rei, Ando Fujiko, Shimokata Hiroshi, Hasegawa Yasuhisa, Nakashima Tsutomu, Sone Michihiko
机构信息
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Toyota Josui Mental Clinic, Aichi, Japan; Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan.
出版信息
J Int Adv Otol. 2018 Aug;14(2):166-169. doi: 10.5152/iao.2018.5442.
OBJECTIVES
The pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk.
MATERIALS AND METHODS
We compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene.
RESULTS
Under the additive model of inheritance, UCP2 polymorphisms showed significant association with a SD risk. The OR was 1.468 (95% confidence interval, 1.056-2.040) with an adjustment for any past history, such as diabetes, dyslipidemia, or hypertension, and for age and sex.
CONCLUSION
Our results imply that the UCP2 (rs660339) polymorphism has a significant association with the risk of developing SD.
目的
突发性感音神经性听力损失，即突发性聋（SD），其病理机制尚不清楚。本研究旨在探讨线粒体解偶联蛋白2（UCP2）基因多态性与SD发病风险之间的关联。
材料与方法
我们比较了83例SD患者和2048例参与国立长寿科学研究所衰老纵向研究的对照者。采用多因素logistic回归分析计算UCP2（rs660339）基因多态性与SD的比值比（OR）。
结果
在遗传加性模型下，UCP2基因多态性与SD发病风险显著相关。在校正了糖尿病、血脂异常或高血压等既往病史以及年龄和性别后，OR为1.468（95%置信区间，1.056 - 2.040）。
结论
我们的结果表明，UCP2（rs660339）基因多态性与SD发病风险显著相关。
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