Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.
Int J Immunogenet. 2011 Jun;38(3):249-54. doi: 10.1111/j.1744-313X.2011.01004.x. Epub 2011 Mar 9.
Sudden sensorineural hearing loss (SSNHL) and Ménière's disease are the most common inner ear diseases in which the causes are unknown. As recent magnetic resonance imaging has demonstrated disruption of the blood-labyrinth barrier in these inner ear diseases, inflammatory reaction associated with increased permeability of the blood vessels may be involved. The genotypes of interleukin 1A (IL1A) (-889C/T; rs1800587) and interleukin 1B (IL1B) (-511C/T; rs16944) were determined using an allele-specific primer-polymerase chain reaction method in 72 patients with SSNHL, 68 patients with Ménière's disease, and 2202 control subjects living almost in the same area as the patients. A significantly higher prevalence of the IL1A-889T allele was observed in SSNHL and Ménière's disease compared with controls, although no significant difference in distribution of IL1B-511C/T genotypes was observed between the patients and controls. Adjusted odd ratios for SSNHL and Ménière's disease risks in the -889TT genotypes were 25.89 (95% confidence interval (CI) 12.19-54.98) and 18.20 (95% CI 7.80-42.46), respectively, after age and gender were taken as moderator variables. Our results suggested that IL1A is closely associated with susceptibility of SSNHL and Ménière's disease.
突发性聋和梅尼埃病是最常见的内耳疾病，其病因不明。最近的磁共振成像显示这些内耳疾病的血迷路屏障破坏，与血管通透性增加相关的炎症反应可能参与其中。采用等位基因特异性引物聚合酶链反应方法，在 72 例突发性聋患者、68 例梅尼埃病患者和 2202 例生活在与患者几乎相同地区的对照者中，确定了白细胞介素 1A（IL1A）（-889C/T；rs1800587）和白细胞介素 1B（IL1B）（-511C/T；rs16944）的基因型。尽管在患者和对照组之间未观察到 IL1B-511C/T 基因型分布存在显著差异，但与对照组相比，突发性聋和梅尼埃病患者的 IL1A-889T 等位基因的发生率明显更高。在调整年龄和性别作为调节变量后，-889TT 基因型的突发性聋和梅尼埃病风险的调整比值比分别为 25.89（95%置信区间（CI）12.19-54.98）和 18.20（95%CI 7.80-42.46）。我们的结果表明，IL1A 与突发性聋和梅尼埃病的易感性密切相关。
