College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Org Biomol Chem. 2018 Aug 22;16(33):6140-6145. doi: 10.1039/c8ob01397g.
An efficient ruthenium-catalyzed synthesis of alkyl-1,3,5-triazies from arylallyl alcohols and biguanides has been developed. The reaction occurred in moderate to good yields and tolerated heterocyclic or aryl allyl alcohols containing functionalities such as alkanes, ethers, and halogens. The reaction proceeds through a one-pot sequence of transfer hydrogenation and condensation steps.
已开发出一种从芳基烯丙醇和双胍出发高效合成烷基-1,3,5-三嗪的钌催化方法。该反应在中等至良好的产率下进行，并能容忍含有烷烃、醚和卤素等官能团的杂环或芳基烯丙醇。该反应通过转移氢化和缩合步骤的一锅法序列进行。
