Rabin B M, Hunt W A, Lee J
Neurobehav Toxicol Teratol. 1986 Jan-Feb;8(1):83-7.
The conditioned taste aversion procedure was used to further assess some behavioral effects of treatment with the putative radioprotectant WR-2721 and the role of the area postrema in mediating the behavioral effects of treatment. Treatment with 40, 150 or 300 mg/kg WR-2721 produced dose-dependent changes in sucrose intake in both control rats and rats with area postrema lesions. The effectiveness of the lesion in disrupting the acquisition of an aversion varied as a function of the dose administered, with the lesions producing the greatest disruption of aversion learning at the lowest dose and little disruption at the highest dose tested. At all dose levels, sucrose intake was greater for the rats with area postrema lesions than for the sham-operated control rats. Treatment with WR-2721 also produced significant decreases in total fluid intake, particularly at the higher dose levels. The results are discussed as indicating that treatment with WR-2721 produces highly toxic effects on behavior and that the use of the compound as a radioprotectant for radiotherapy requires additional assessment of its effects on brain function and behavior.
条件性味觉厌恶程序被用于进一步评估假定的辐射防护剂WR - 2721治疗的一些行为效应，以及最后区在介导治疗的行为效应中的作用。给予40、150或300mg/kg的WR - 2721治疗，在对照大鼠和最后区损伤的大鼠中均产生了蔗糖摄入量的剂量依赖性变化。损伤对厌恶习得的破坏效果随给药剂量而变化，在最低测试剂量时损伤对厌恶学习的破坏最大，而在最高测试剂量时破坏很小。在所有剂量水平下，最后区损伤的大鼠的蔗糖摄入量均高于假手术对照大鼠。给予WR - 2721治疗还导致总液体摄入量显著减少，尤其是在较高剂量水平时。讨论结果表明，给予WR - 2721治疗对行为产生了高度毒性作用，并且将该化合物用作放射治疗的辐射防护剂需要对其对脑功能和行为的影响进行额外评估。
