阿维菌素B1a在豚鼠离体肠中诱导的γ-氨基丁酸依赖性运动
gamma-Aminobutyric acid-dependent motility induced by avermectin B1a in the isolated intestine of the guinea pig.
作者信息
Kerr D I, Ong J
出版信息
Neurosci Lett. 1986 Mar 28;65(1):7-10. doi: 10.1016/0304-3940(86)90111-4.
In the isolated ileum of the guinea pig, neurally mediated rhythmic longitudinal mechanical activity was induced by avermectin, a macrolide anthelmintic that releases gamma-aminobutyric acid (GABA) and modulates the GABAA-receptor-ionophore complex. This avermectin-induced activity was dependent on GABA, being reduced or abolished by bicuculline, a GABAA-receptor antagonist, and by 3-mercaptopropionic acid which prevents neural GABA release. These results provide additional direct evidence that GABA is a functional neurotransmitter in the myenteric plexus of the guinea pig intestine, evidently involved in the regulation of intestinal motility.
在豚鼠的离体回肠中，大环内酯类驱虫药阿维菌素可诱导神经介导的节律性纵向机械活动，该药物可释放γ-氨基丁酸（GABA）并调节GABAA受体-离子载体复合物。这种阿维菌素诱导的活动依赖于GABA，GABAA受体拮抗剂荷包牡丹碱和阻止神经GABA释放的3-巯基丙酸可使其降低或消除。这些结果提供了额外的直接证据，表明GABA是豚鼠肠道肌间神经丛中的一种功能性神经递质，显然参与肠道运动的调节。
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