Department of Radiological Technology, Kagoshima University Hospital, Kagoshima City, Japan.
Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, Japan.
J Magn Reson Imaging. 2019 Feb;49(2):565-573. doi: 10.1002/jmri.26196. Epub 2018 Aug 13.
Diffusion-weighted imaging (DWI) has been used for the detection and characterization of liver tumors because it has excellent contrast resolution. DWI using short tau inversion recovery (STIR) can improve tumor-to-liver contrast after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration that shortens the T relaxation of liver parenchyma.
To quantitatively and qualitatively compare the conspicuity of malignant liver tumors on DWI after Gd-EOB-DTPA administration between STIR and chemical shift selective (CHESS) sequences.
Single-institution retrospective study.
Fifty-seven patients with histologically confirmed malignant liver tumors were evaluated.
FIELD STRENGTH/SEQUENCE: Low b-value DWIs with STIR and CHESS sequences 18-20 minutes after Gd-EOB-DTPA administration were acquired at 1.5T.
Tumor contrast-to-noise ratio (CNR) and visual grade of tumor conspicuity on DWI between STIR and CHESS sequences were compared.
Paired Student's t-test and the Wilcoxon signed rank-test were applied. P < 0.05 was considered statistically significant.
The mean tumor CNR and visual grade of tumor conspicuity on DWI were significantly higher for STIR than for CHESS (both P < 0.001). Regardless of the presence of chronic liver disease, the mean CNR (normal liver 33.5 ± 19.8 vs. 15.7 ± 12.2, P < 0.001; chronic liver disease 19.6 ± 11.0 vs. 9.2 ± 7.8, P < 0.001) and the visual conspicuity grade (normal liver 3.36 ± 0.64 vs. 2.56 ± 0.77, P < 0.001; chronic liver disease 2.94 ± 0.80 vs. 2.25 ± 0.84, P = 0.001) were significantly higher for STIR than for CHESS. Mean CNR and the visual conspicuity grade were also significantly higher for STIR than for CHESS in patients with hepatocellular carcinomas (CNR 18.1 ± 10.5 vs. 8.8 ± 7.2, P < 0.001; visual grade 2.88 ± 0.83 vs. 2.22 ± 0.87, P = 0.001) or metastases (CNR 35.0 ± 19.3 vs. 16.2 ± 13.1, P < 0.001; visual grade 3.45 ± 0.51 vs. 2.59 ± 0.73, P < 0.001).
DWI using STIR may be more helpful for depicting malignant liver tumors after Gd-EOB-DTPA administration compared with DWI using CHESS.
3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:565-573.
扩散加权成像（DWI）因其具有出色的对比度分辨率而被用于检测和描述肝脏肿瘤。使用短回波时间反转恢复（STIR）的 DWI 可以在钆乙氧基苯甲基二乙三胺五乙酸（Gd-EOB-DTPA）给药后提高肿瘤与肝脏的对比，从而缩短肝脏实质的 T 弛豫时间。
定量和定性比较 Gd-EOB-DTPA 给药后 STIR 和化学位移选择（CHESS）序列上恶性肝脏肿瘤的 DWI 对比。
单机构回顾性研究。
57 例经组织学证实的恶性肝脏肿瘤患者。
磁场强度/序列：在 1.5T 上采集 Gd-EOB-DTPA 给药后 18-20 分钟的低 b 值 DWI，使用 STIR 和 CHESS 序列。
比较 STIR 和 CHESS 序列上肿瘤的对比噪声比（CNR）和肿瘤显影的视觉分级。
采用配对学生 t 检验和 Wilcoxon 符号秩检验。P < 0.05 被认为具有统计学意义。
STIR 上的平均肿瘤 CNR 和肿瘤显影的视觉分级均显著高于 CHESS（均 P < 0.001）。无论是否存在慢性肝病，STIR 上的平均 CNR（正常肝脏 33.5 ± 19.8 比 15.7 ± 12.2，P < 0.001；慢性肝病 19.6 ± 11.0 比 9.2 ± 7.8，P < 0.001）和视觉显影分级（正常肝脏 3.36 ± 0.64 比 2.56 ± 0.77，P < 0.001；慢性肝病 2.94 ± 0.80 比 2.25 ± 0.84，P = 0.001）均显著高于 CHESS。STIR 上的平均 CNR 和视觉显影分级也显著高于 CHESS，用于肝细胞癌（CNR 18.1 ± 10.5 比 8.8 ± 7.2，P < 0.001；视觉分级 2.88 ± 0.83 比 2.22 ± 0.87，P = 0.001）或转移瘤（CNR 35.0 ± 19.3 比 16.2 ± 13.1，P < 0.001；视觉分级 3.45 ± 0.51 比 2.59 ± 0.73，P < 0.001）。
与 CHESS 相比，使用 STIR 的 DWI 可能更有助于描绘 Gd-EOB-DTPA 给药后恶性肝脏肿瘤。
3 级 技术功效：第 2 阶段 J. Magn. Reson. Imaging 2019;49:565-573.
