Yazıcı Selçuk, Güneş Soner, Kurtuluş-Çokboz Melike, Kemer Özlem, Baranlı Gülce, Aşık-Akman Sezin, Can Demet
Departments of Pediatrics, Balıkesir University Faculty of Medicine, Balıkesir, Turkey.
Departments of Public Health, Balıkesir University Faculty of Medicine, Balıkesir, Turkey.
Turk J Pediatr. 2018;60(1):41-49. doi: 10.24953/turkjped.2018.01.006.
Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G, Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49. The increase in the prevalence of allergic diseases in pre-school children who are often at home may be due to an increase in house dust mite sensitivity, which is rarely expected in this age group. In our study, it was aimed to investigate allergen sensitivities, especially house dust mite sensitivity in pre-school children with allergic disease complaints by skin prick test (SPT). Two hundred and twenty children admitted to the Pediatric Allergy and Asthma Clinic of Balıkesir University between October 2015 and October 2016 diagnosed with asthma, allergic rhinitis, food allergy, atopic dermatitis or urticaria were involved in the retrospective cross-sectional study. Allergen groups used in SPT were Dermatophagoides farina (Derf), Dermatophagoides pteronyssinus (Der p), Alternaria alternata, cat epithelium, pollen mixture and food mixture. Average age of the 220 patients was 2.98 years (2.75-3.21). SPT was positive in 55.9% of patients. Sixteen percent were monosensitized and 73.8% were polysensitized. Seventy two children (32.7%) were sensitive to Der f and 67 (30.4%) were sensitive to Der p. There was no difference between SPT positivity and gender (p > 0.05). Ninty-five children were diagnosed with asthma, 38 with asthma and allergic rhinitis, 63 with food allergy and 24 with urticaria and/or atopic dermatitis. SPT positivity was significantly higher in the asthma and allergic rhinitis group than other groups. As the age increased, significant increases in the sensitivities of Der f (p < 0.01), Der p (P < 0.01) and A. alternata (p < 0.05) and a significant decrease for food panel sensitivity (p < 0.01) were detected. Even though skin and food allergies were included in our study, house dust mite sensitivity was found much higher than other studies reporting ranges between 3.5-23% in children of the same age group with mainly respiratory complaints. It is concluded that the probable reasons for this increase, especially geographical features, should be investigated in different areas and in larger number of studies.
亚齐奇·S、居内什·S、库尔图卢什 - 乔克博兹·M、凯末尔·Ö、巴兰勒·G、阿西克 - 阿克曼·S、坎·D。有过敏症状的学龄前儿童的过敏原变异性和屋尘螨敏感性。《土耳其儿科学杂志》2018年；60: 41 - 49。经常在家的学龄前儿童过敏疾病患病率增加可能是由于屋尘螨敏感性增加，而在这个年龄组中这种情况很少被预期到。在我们的研究中，旨在通过皮肤点刺试验（SPT）调查有过敏疾病症状的学龄前儿童的过敏原敏感性，尤其是屋尘螨敏感性。2015年10月至2016年10月期间入住巴勒克埃西尔大学儿科过敏与哮喘诊所，被诊断患有哮喘、过敏性鼻炎、食物过敏、特应性皮炎或荨麻疹的220名儿童参与了这项回顾性横断面研究。SPT中使用的过敏原组有粉尘螨（Derf）、户尘螨（Der p）、链格孢、猫上皮、花粉混合物和食物混合物。220名患者的平均年龄为2.98岁（2.75 - 3.21）。55.9%的患者SPT呈阳性。16%为单敏，73.8%为多敏。72名儿童（32.7%）对Der f敏感，67名（30.4%）对Der p敏感。SPT阳性率与性别之间无差异（p > 0.05）。95名儿童被诊断患有哮喘，38名患有哮喘和过敏性鼻炎，63名患有食物过敏，24名患有荨麻疹和/或特应性皮炎。哮喘和过敏性鼻炎组的SPT阳性率显著高于其他组。随着年龄增加，检测到Der f（p < 0.01）、Der p（P < 0.01）和链格孢（p < 0.05）的敏感性显著增加，而食物组敏感性显著降低（p < 0.01）。尽管我们的研究纳入了皮肤和食物过敏，但发现屋尘螨敏感性远高于其他研究报道的同年龄组主要有呼吸道症状儿童中3.5 - 23%的范围。得出结论，这种增加的可能原因，尤其是地理特征，应在不同地区进行更多研究来调查。
