Ping Jie-Dan, Zhao Jun-Wei, Sun Xiao-Xu, Wu Fan, Jiang Zhi-Yun, Cheng Zhe, Zheng Lei, Xue Hai-Kuo, Yang Jing-Jing, Ming Liang
Clinical Laboratory, Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Exp Ther Med. 2020 Mar;19(3):1908-1914. doi: 10.3892/etm.2019.8367. Epub 2019 Dec 23.
The etiology of urticaria is heterogeneous and allergic responses may be involved in it. The aim of the present study was to investigate the prevalence and distribution of sensitivity to inhaled and food allergens among patients with urticaria in Henan province (China). The levels of specific immunoglobulin E (sIgE) were detected using the AllergyScreen test and a total of 524/1,091 cases (48.0%) tested positive for sIgE to at least one of the 19 allergens. The most common inhaled allergens the urticaria patients were sensitive to were (34.5%), cockroach (12.5%) and tree pollen mix (11.1%), while the food allergens with the highest rate of allergic reactions were cashew nut (8.1%), shrimp (6.8%) and crab (6.4%). The positive rates for , dog hair, cockroach, mold mix, tree pollen mix and shrimp in the chronic urticaria group were higher than those in the acute urticaria group (P<0.05). Furthermore, positive rates for the majority of allergens were higher in males than in females and were significantly different between age groups (P<0.05). The results of the present study provided information on the characteristics of allergen sensitization of patients with urticaria and may facilitate the prevention, diagnosis and management of urticaria in Henan province.
荨麻疹的病因具有异质性，可能涉及过敏反应。本研究的目的是调查中国河南省荨麻疹患者对吸入性和食物过敏原的敏感性患病率及分布情况。使用AllergyScreen检测特异性免疫球蛋白E（sIgE）水平，在1091例患者中，共有524例（48.0%）对19种过敏原中的至少一种sIgE检测呈阳性。荨麻疹患者最常见的吸入性过敏原是（34.5%）、蟑螂（12.5%）和混合树花粉（11.1%），而过敏反应发生率最高的食物过敏原是腰果（8.1%）、虾（6.8%）和蟹（6.4%）。慢性荨麻疹组中、狗毛、蟑螂、混合霉菌、混合树花粉和虾的阳性率高于急性荨麻疹组（P<0.05）。此外，大多数过敏原的阳性率男性高于女性，且在不同年龄组之间存在显著差异（P<0.05）。本研究结果提供了荨麻疹患者过敏原致敏特征的信息，可能有助于河南省荨麻疹的预防、诊断和管理。
