氟康唑 1200mg/天口服治疗与 HIV 相关隐球菌性脑膜炎的非洲成年人 QT 间期的影响。
Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
机构信息
Centre for Global Health, Institute for Infection and Immunity, St George's University of London.
Joint first authors.
出版信息
AIDS. 2018 Sep 24;32(15):2259-2261. doi: 10.1097/QAD.0000000000001961.
Abstract
: We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR: -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
摘要
我们评估了氟康唑 1200mg/天对隐球菌性脑膜炎患者 QT 间期的影响。氟康唑治疗组从基线到第 7 天的平均校正 QT（QTc）变化为 10.1ms（IQR：-28 至 46ms），而未服用氟康唑的患者为-12.6ms（IQR：-39 至 13.5ms）（P=0.04）。氟康唑治疗组未观察到 QTc 测量值超过 500ms 的显著增加。然而，纠正任何电解质失衡并避免可能增加 QTc 的同时使用药物仍然很重要。
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