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Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).肝素诱导的血小板减少症（HIT）的分子和细胞发病机制。
Autoimmun Rev. 2018 Oct;17(10):1046-1052. doi: 10.1016/j.autrev.2018.05.003. Epub 2018 Aug 10.
2
Heparin-induced thrombocytopenia.肝素诱导的血小板减少症。
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[Heparin-induced thrombocytopenia (HIT): pathogenesis, laboratory test, and treatment].[肝素诱导的血小板减少症（HIT）：发病机制、实验室检查及治疗]
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Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).肝素诱导的血小板减少症（HIT）中自身抗原的原子特征。
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Contemporary standards for the diagnosis and treatment of heparin-induced thrombocytopenia (HIT).肝素诱导的血小板减少症（HIT）的当代诊断和治疗标准。
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Heparin-induced thrombocytopenia: natural history, diagnosis, and management.肝素诱导的血小板减少症：自然病程、诊断与管理
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Heparin-induced thrombocytopenia: some working hypotheses on pathogenesis, diagnostic strategies and treatment.肝素诱导的血小板减少症：关于发病机制、诊断策略及治疗的一些工作假说
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[Heparin induced thrombocytopenia].[肝素诱导的血小板减少症]
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Clinical presentation of heparin-induced thrombocytopenia.肝素诱导的血小板减少症的临床表现。
Semin Hematol. 1998 Oct;35(4 Suppl 5):9-16; discussion 35-6.
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Management of heparin-induced thrombocytopenia.肝素诱导的血小板减少症的管理。
Expert Opin Pharmacother. 2012 May;13(7):987-1006. doi: 10.1517/14656566.2012.678834. Epub 2012 Apr 5.

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Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia.肝素诱导的血小板减少症中单核细胞激活的结构和功能变化
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Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis.从 HIT 患者中克隆的抗体为 HIT 发病机制提供了新的线索。
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Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.肝素诱导的血小板减少症抗体识别 PF4-VWF 复合物有助于血栓形成。
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1
Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.多聚磷酸盐/血小板第4因子复合物可在肝素诱导的血小板减少症中介导不依赖肝素的血小板活化。
Blood Adv. 2016 Nov 22;1(1):62-74. doi: 10.1182/bloodadvances.2016000877. eCollection 2016 Nov 29.
2
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity.抗血小板因子 4/多阴离子抗体介导一种新的自身免疫机制。
Nat Commun. 2017 May 22;8:14945. doi: 10.1038/ncomms14945.
3
Platelet factor 4/heparin complexes present epitopes differently on solid-phase vs platelet surfaces.血小板因子4/肝素复合物在固相表面和血小板表面呈现不同的表位。
Blood. 2017 Jun 29;129(26):3498-3501. doi: 10.1182/blood-2017-02-769786. Epub 2017 May 5.
4
Heparin-induced thrombocytopenia.肝素诱导的血小板减少症。
Blood. 2017 May 25;129(21):2864-2872. doi: 10.1182/blood-2016-11-709873. Epub 2017 Apr 17.
5
Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL HIT-Ab] for the diagnosis of immune heparin-induced thrombocytopenia.用于诊断免疫性肝素诱导的血小板减少症的自动化乳胶免疫比浊测定法（HemosIL HIT-Ab）的性能特征。
Thromb Res. 2017 May;153:108-117. doi: 10.1016/j.thromres.2017.03.010. Epub 2017 Mar 11.
6
Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia.肝素诱导的血小板减少症患者队列的临床结局。
Am J Hematol. 2017 Aug;92(8):730-738. doi: 10.1002/ajh.24759. Epub 2017 Apr 26.
7
Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.内皮抗原组装导致肝素诱导的血小板减少症中的血栓形成并发症。
J Clin Invest. 2017 Mar 1;127(3):1090-1098. doi: 10.1172/JCI90958. Epub 2017 Feb 20.
8
Inappropriate documentation of heparin allergy in the medical record because of misdiagnosis of heparin-induced thrombocytopenia: frequency and consequences.由于肝素诱导的血小板减少症误诊，导致医疗记录中肝素过敏记录不当：频率和后果。
J Thromb Haemost. 2017 Feb;15(2):370-374. doi: 10.1111/jth.13565. Epub 2016 Dec 24.
9
Single-molecule force spectroscopy applied to heparin-induced thrombocytopenia.应用于肝素诱导的血小板减少症的单分子力谱分析
J Mol Recognit. 2017 Mar;30(3). doi: 10.1002/jmr.2585. Epub 2016 Oct 28.
10
TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice.TULA-2（T细胞泛素配体-2）抑制小鼠IgG IIA血小板Fc受体（FcγRIIA）信号通路及肝素诱导的血小板减少症。
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2315-2323. doi: 10.1161/ATVBAHA.116.307979. Epub 2016 Oct 20.

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

作者信息

Rauova Lubica, Arepally Gowthami, Poncz Mortimer, Cines Douglas B

机构信息

Division of Hematology, Department of Pediatrics, Childrens Hospital of Philadelphia, USA; Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, USA.

Division of Hematology, Department of Medicine, Duke University School of Medicine, USA.

出版信息

Autoimmun Rev. 2018 Oct;17(10):1046-1052. doi: 10.1016/j.autrev.2018.05.003. Epub 2018 Aug 10.

DOI:10.1016/j.autrev.2018.05.003
PMID:30103043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6201246/
Abstract
摘要