Department of Health Sciences, Oita University of Nursing and Health Sciences, Oita 870-1163, Japan.
Division of Nephrology and Metabolism, Tokai University School of Medicine, Kanagawa 259-119, Japan.
Int J Mol Sci. 2018 Aug 10;19(8):2352. doi: 10.3390/ijms19082352.
Transforming growth factor (TGF)-β signaling is not only important in skeletal development, but also essential in bone remodeling in adult bone. The bone remodeling process involves integrated cell activities induced by multiple stimuli to balance bone resorption and bone formation. TGF-β plays a role in bone remodeling by coordinating cell activities to maintain bone homeostasis. However, mineral metabolism disturbance in chronic kidney disease (CKD) results in abnormal bone remodeling, which leads to ectopic calcification in CKD. High circulating levels of humoral factors such as parathyroid hormone, fibroblast growth factor 23, and Wnt inhibitors modulate bone remodeling in CKD. Several reports have revealed that TGF-β is involved in the production and functions of these factors in bone. TGF-β may act as a factor that mediates abnormal bone remodeling in CKD.
转化生长因子 (TGF)-β 信号不仅在骨骼发育中很重要，而且在成人骨骼的骨重建中也是必不可少的。骨重建过程涉及到多种刺激诱导的细胞综合活动，以平衡骨吸收和骨形成。TGF-β 通过协调细胞活动来维持骨稳态，在骨重建中发挥作用。然而，慢性肾脏病 (CKD) 中的矿物质代谢紊乱导致异常的骨重建，从而导致 CKD 中的异位钙化。循环中高水平的体液因子，如甲状旁腺激素、成纤维细胞生长因子 23 和 Wnt 抑制剂，调节 CKD 中的骨重建。有几项报告表明，TGF-β 参与了这些因子在骨中的产生和功能。TGF-β 可能作为一种因子，介导 CKD 中的异常骨重建。
Zotero 插件