Rybalkin S D, Sobolev A S
Radiobiologiia. 1986 Mar-Apr;26(2):167-70.
An increase in the activity of cyclic nucleotide phosphodiesterase was noted during the first hour following irradiation of mice with a dose of 11 Gy and after in vitro irradiation of the thymocyte suspension. Using the methods of gel-filtration and sedimentation and in studying the kinetic characteristics it was shown that the effect of radiation changed the degree of the enzyme aggregation, i. e. the share of the dissociated forms, which possessed a higher catalytic activity, increased.
在用11 Gy剂量照射小鼠以及对胸腺细胞悬液进行体外照射后的第一个小时内，观察到环核苷酸磷酸二酯酶的活性增加。使用凝胶过滤和沉降方法并研究其动力学特性表明，辐射效应改变了酶的聚集程度，即具有较高催化活性的解离形式的比例增加。
