Watson F, Rusbridge C, Packer R M A, Casey R A, Heath S, Volk H A
The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, UK; Fitzpatrick Referrals, Halfway Lane, Godalming, Surrey, GU7 2QQ, UK.
Fitzpatrick Referrals, Halfway Lane, Godalming, Surrey, GU7 2QQ, UK; School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Main Academic Building (VSM), Daphne Jackson Road, Guildford, Surrey, GU2 7AL, UK.
Vet J. 2018 Aug;238:1-9. doi: 10.1016/j.tvjl.2018.06.001. Epub 2018 Jun 7.
Psychiatric comorbidities affect a large percentage of people with epilepsy and have a detrimental impact on their quality of life. Recently, behavioural comorbidities, with similar characteristics to human psychiatric diseases, have been identified in dogs with idiopathic epilepsy. In particular, behaviours motivated by the fear-anxiety emotional system have been found to be associated with the occurrence of idiopathic epilepsy in both dogs receiving anti-epileptic drugs, and drug-naïve dogs. There has been little research into the relationship between epilepsy and behavioural signs, and even less into potential treatment protocols. The following article will review available literature from human medicine to describe the current state of knowledge about the bi-directional relationship between anxiety and epilepsy, draw parallels from reported anxiogenic and anxiolytic properties of anti-epileptic drugs and attempt to provide pharmaceutical and behavioural guidance for veterinary patients with epilepsy and comorbid anxiety.
精神疾病共病影响着很大比例的癫痫患者，对他们的生活质量产生不利影响。最近，在特发性癫痫犬中发现了具有与人类精神疾病相似特征的行为共病。特别是，在接受抗癫痫药物治疗的犬和未使用过药物的犬中，由恐惧 - 焦虑情绪系统驱动的行为都被发现与特发性癫痫的发生有关。关于癫痫与行为症状之间的关系研究很少，而关于潜在治疗方案的研究更少。以下文章将回顾来自人类医学的现有文献，以描述焦虑与癫痫之间双向关系的当前知识状态，借鉴抗癫痫药物已报道的致焦虑和抗焦虑特性，并尝试为患有癫痫和共病焦虑的兽医患者提供药物和行为指导。
