Dousti Fatemeh, Shahrisa Arman, Ansari Hossein, Hajjari Mohammadreza, Tahmasebi Birgani Yaser, Mohammadiasl Javad, Tahmasebi Birgani Maryam
Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University, Tehran, Iran.
Pathol Res Pract. 2018 Sep;214(9):1462-1466. doi: 10.1016/j.prp.2018.08.006. Epub 2018 Aug 7.
Long non-coding RNAs (lncRNAs), are lengthy noncoding transcripts with pivotal roles in biological pathways including cell cycle, apoptosis and chromatin remodeling. Aberrant expression of lncRNAs has been strongly connected with tumor progression and metastasis. However, the prognostic significance of lncRNAs in diffuse large-B-cell lymphoma (DLBCL) remains unclear. In this study, the expression levels of 189 approved lncRNAs were considered in DLBCL patients using several different genomic and transcriptome datasets. The analyses showed that the lncRNA GAS5 allocated the maximum score of RNA dysregulation and can be considered as good choice in DLBCLs' researches.
长链非编码RNA（lncRNAs）是一类长链非编码转录本，在包括细胞周期、细胞凋亡和染色质重塑等生物学途径中发挥关键作用。lncRNAs的异常表达与肿瘤进展和转移密切相关。然而，lncRNAs在弥漫性大B细胞淋巴瘤（DLBCL）中的预后意义仍不明确。在本研究中，利用多个不同的基因组和转录组数据集，分析了189种已被认可的lncRNAs在DLBCL患者中的表达水平。分析表明，lncRNA GAS5的RNA失调得分最高，可被视为DLBCL研究中的一个良好选择。
