Martínez García María, Trincado Aznar Pablo, Pérez Fernández Leticia, Azcona Monreal Isabel, López Alaminos María Elena, Acha Pérez Javier, Albero Gamboa Ramón
Servicio de Endocrinología y Nutrición, Hospital Universitario Miguel Servet, Zaragoza, España.
Servicio de Endocrinología y Nutrición, Hospital Universitario Miguel Servet, Zaragoza, España.
Nefrologia (Engl Ed). 2019 Jan-Feb;39(1):73-79. doi: 10.1016/j.nefro.2018.05.008. Epub 2018 Aug 10.
Both dietary restriction of sodium chloride (NaCl) and treatment with thiazides have been used in hypercalciuric patients.
To calculate regular salt intake and investigate the correlation between natriuresis and urinary calcium with usual diet (B) and after changing the amount of NaCl intake and administration of thiazides.
Nineteen healthy young individuals had their diet replaced by 2l of Nutrison Low Sodium (500mg sodium/day) daily for two days. Then, 5g of NaCl were added every two days («5», «10» and «15»), administering 50mg (H50) and 100mg (H100) of Higroton on the last two days. Blood sodium, plasma renin activity (PRA) and aldosterone were determined in venous blood samples, as were urinary sodium and calcium.
Wilcoxon t-test and the Pearson linear correlation were calculated.
Urinary Na (mEq/24h): 210.3±87.6 («B»); 42.7±20.4 («5»); 135.5±50.6 («10»); 225.5±56.7 («15»). Urinary calcium (mg/24h): 207.8±93.6 («B»); 172.8±63.1 («5»); 206.2±87.7 («10»); 227.4±84.1 («15»). A positive correlation was observed between natriuresis and urinary calcium in «10» (r=0.47) and «15» (r=0.67). After Higroton, natriuresis: 232.3±50.7; 377±4 (H50); 341.1±68.4 (H100); Ca in urine: 209.8±57.4; 213.2±67.6 (H50); 159.1±52.2 (H100).
Salt intake in the population studied was estimated to be 14.9±4.9g/day with a positive correlation found between sodium and calcium urine output with daily intakes of 11.25 and 16.25g of salt. With the usual intake, for each gram of salt, urinary calcium increased by 5.46 mg/24 h and with 100mg of Higroton it decreased by 50.7mg/24h. These data could be useful for the management of patients with excretory hypercalciuria or hypoparathyroidism.
限制氯化钠（NaCl）饮食和噻嗪类药物治疗均已应用于高钙尿症患者。
计算常规盐摄入量，并研究在正常饮食（B）情况下以及改变NaCl摄入量和给予噻嗪类药物后，钠利尿与尿钙之间的相关性。
19名健康年轻个体，连续两天每天用2升低钠全营养素（每日含500毫克钠）替代其饮食。然后，每两天添加5克NaCl（“5”、“10”和“15”），在最后两天给予50毫克（H50）和100毫克（H100）氢氯噻嗪。测定静脉血样本中的血钠、血浆肾素活性（PRA）和醛固酮，以及尿钠和尿钙。
计算Wilcoxon t检验和Pearson线性相关性。
尿钠（毫当量/24小时）：210.3±87.6（“B”）；42.7±20.4（“5”）；135.5±50.6（“10”）；225.5±56.7（“15”）。尿钙（毫克/24小时）：207.8±93.6（“B”）；172.8±63.1（“5”）；206.2±87.7（“10”）；227.4±84.1（“15”）。在“10”（r = 0.47）和“15”（r = 0.67）中观察到钠利尿与尿钙之间呈正相关。给予氢氯噻嗪后，钠利尿：232.3±50.7；377±4（H50）；341.1±68.（H100）；尿钙：209.8±57.4；213.2±67.6（H50）；159.1±52.2（H100）。
研究人群的盐摄入量估计为14.9±4.9克/天，在每日摄入11.25克和16.25克盐时，尿钠和尿钙输出之间呈正相关。在正常摄入量时，每克盐使尿钙增加5.46毫克/24小时，而给予100毫克氢氯噻嗪时，尿钙减少50.7毫克/24小时。这些数据可能有助于排泄性高钙尿症或甲状旁腺功能减退症患者的管理。
