用麻醉揭示意识的要素。
Using Anesthesia to Reveal the Elements of Consciousness.
机构信息
Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Trends Cogn Sci. 2018 Nov;22(11):961-962. doi: 10.1016/j.tics.2018.07.016. Epub 2018 Aug 10.
Abstract
General anesthesia provides an invaluable experimental tool to probe the essential neural circuits that underlie consciousness. A new study reports that cholinergic stimulation of the prefrontal cortex restores wake-like behaviors in anesthetized rodents, suggesting that cholinergic inputs to the prefrontal cortex play a fundamental role in modulating consciousness.
摘要
全身麻醉为探究意识的基本神经回路提供了一个非常有价值的实验工具。一项新的研究报告称，刺激前额叶皮层的胆碱能可恢复麻醉状态下啮齿动物的觉醒样行为，这表明前额叶皮层的胆碱能输入在调节意识方面起着基础性作用。
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本文引用的文献
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Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.负责维持麻醉性意识丧失的脑桥中神经元的位置。
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Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness.全麻上下行机制调节意识不同维度。
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