Pouget J, Pellissier J F, Jean P, Jouglard J, Toga M, Serratrice G
Rev Neurol (Paris). 1986;142(1):34-41.
A case of peripheral neuropathy following cimetidine treatment is reported. Four days after beginning cimetidine (200 mg four times a day), the patient developed muscle pain and a symmetric motor neuropathy in all 4 limbs, predominant distally and in the lower limbs. Cimetidine was discontinued. Within seven days motor function began to return and within five months recovery was complete. Electrophysiological studies showed an axonal neuropathy. Morphometric studies revealed loss of large myelinated fibers in some fascicles while other fascicles were normal. Teasing studies showed predominant axonal lesions. Microvasculitis was present in the epineurium. Such findings suggest a role for small-vessel immune-complex vasculitis in the pathogenesis of this cimetidine-induced peripheral neuropathy.
报告1例西咪替丁治疗后发生的周围神经病。开始使用西咪替丁（每日4次，每次200mg）4天后，患者出现肌肉疼痛及四肢对称性运动神经病，以远端及下肢为主。停用西咪替丁。7天内运动功能开始恢复，5个月内完全恢复。电生理研究显示为轴索性神经病。形态学研究发现部分束中大的有髓纤维丢失，而其他束正常。分离研究显示主要为轴索损害。神经外膜存在微血管炎。这些发现提示小血管免疫复合物性血管炎在这种西咪替丁诱导的周围神经病发病机制中起作用。
