Serrano-Mollar Anna
Departamento de Patología Experimental, Instituto de Investigaciones Biomédicas de Barcelona IIBB-CSIC-IDIBAPS, Rosselló, 161, 08036 Barcelona, Spain.
Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Med Sci (Basel). 2018 Aug 13;6(3):64. doi: 10.3390/medsci6030064.
Idiopathic pulmonary fibrosis is a fatal disease with no effective or curative treatment options. In recent decades, cell-based therapies using stem cells or lung progenitor cells to regenerate lung tissue have experienced rapid growth in both preclinical animal models and translational clinical studies. In this review, the current knowledge of these cell therapies is summarized. Although further investigations are required, these studies indicate that cell therapies are a promising therapeutic approach for the treatment of idiopathic pulmonary fibrosis.
特发性肺纤维化是一种致命疾病,没有有效的治疗方法或治愈手段。近几十年来,使用干细胞或肺祖细胞来再生肺组织的细胞疗法在临床前动物模型和转化临床研究中都经历了快速发展。在这篇综述中,总结了目前关于这些细胞疗法的知识。尽管还需要进一步研究,但这些研究表明细胞疗法是治疗特发性肺纤维化的一种有前景的治疗方法。