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How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?

作者信息

Fan Ping, Jordan V Craig

机构信息

Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Cell Death Dis. 2018 Aug 13;9(8):842. doi: 10.1038/s41419-018-0516-y.

DOI:10.1038/s41419-018-0516-y
PMID:30104654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6089992/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/6089992/75f9e1b156a2/41419_2018_516_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/6089992/75f9e1b156a2/41419_2018_516_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/6089992/75f9e1b156a2/41419_2018_516_Fig1_HTML.jpg

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Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.内质网应激传感器PERK对核因子-κB激活的调节作用,以介导雌激素诱导的乳腺癌细胞凋亡。
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Mol Cancer Res. 2015 Oct;13(10):1367-76. doi: 10.1158/1541-7786.MCR-14-0494. Epub 2015 Jun 26.
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内质网应激靶向治疗乳腺癌。
Cell Commun Signal. 2022 Nov 7;20(1):174. doi: 10.1186/s12964-022-00964-7.
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Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer.雌激素受体复合物触发或延迟长期雌激素剥夺的乳腺癌中雌激素诱导的细胞凋亡。
Front Endocrinol (Lausanne). 2022 Mar 10;13:869562. doi: 10.3389/fendo.2022.869562. eCollection 2022.
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Target Oncol. 2022 Mar;17(2):111-124. doi: 10.1007/s11523-022-00870-5. Epub 2022 Mar 15.
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