Little is known about the diagnosis and surgical management of head and neck conditions in patients with HIV/AIDS. This study was conducted to characterize the otorhinolaryngological (ORL) profiles, surgical interventions and outcomes in patients with HIV/AIDS. This retrospective study included patients with HIV/AIDS who underwent head and neck surgeries at You'an Hospital from November 2009 to February 2017. Patients' ages, ORL diagnoses and surgical interventions for all ORL surgeries were recorded. We identified 57 ORL surgeries in 52 patients during this time. The mean age of the patients was 37.7 ± 12.8 years, with a predominance of male patients (90.4%). The three most common surgical diagnoses were chronic tonsillitis (19.3%), followed by chronic rhinosinusitis (CRS) (14.0%) and vocal polyps (8.8%). The three most common surgeries performed were tonsillectomy (19.3%), endoscopic sinus surgery + radiofrequency ablation of the inferior turbinate (14.0%) and vocal cord polypectomy (8.8%). No mortality occurred in the 30 days after surgery, but 2 patients (3.8%) developed post-operative surgical site infections (SSI). These findings provide information on ORL manifestations and surgical interventions in patients with HIV/AIDS and may assist in the achievement of the most appropriate treatments for this patient population.