鞘内注射吗啡在接受全膝关节和髋关节置换术的不同患者群体中的安全性和副作用情况。
Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty.
作者信息
Hess Shane R, Lahaye Laura A, Waligora Andrew C, Sima Adam P, Jiranek William A, Golladay Gregory J
机构信息
Department of Orthopedics, Center for Orthopedic Research and Education, The CORE Institute, 18444 N. 25th Ave, Phoenix, AZ, 85023, USA.
Department of Anesthesiology, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Eur J Orthop Surg Traumatol. 2019 Jan;29(1):125-129. doi: 10.1007/s00590-018-2293-9. Epub 2018 Aug 13.
Intrathecal morphine (ITM) can be useful for postoperative analgesia following lower extremity joint arthroplasty, but concerns exist regarding potential dose-related side effects. In this study, we examined the safety and efficacy of ITM in patients undergoing lower extremity joint arthroplasty. We hypothesized that there would be (1) direct relationship between dosing and side effects, and (2) an inverse relationship between ITM dosing and 24-hour postoperative opioid requirement.
鞘内注射吗啡（ITM）可用于下肢关节置换术后的镇痛，但对于潜在的剂量相关副作用存在担忧。在本研究中，我们检查了ITM在接受下肢关节置换术患者中的安全性和有效性。我们假设：（1）剂量与副作用之间存在直接关系，以及（2）ITM剂量与术后24小时阿片类药物需求量之间存在反比关系。
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