Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University., Gustav Wieds Vej 14, 8000, Aarhus C, Denmark.
Chemistry. 2018 Oct 9;24(56):14946-14949. doi: 10.1002/chem.201804077. Epub 2018 Sep 11.
The development of a nickel-mediated aminocarbonylation utilizing NN -pincer Ni-complexes, alkylzinc reagents, stoichiometric carbon monoxide and amines is described for the first time, which can be adapted to late-stage carbon-isotope labeling. This work expands the scope of the highly established palladium-promoted version of the reaction, by allowing carbon-sp fragments to take part in the three-component reaction. Finally, the results obtained show a remarkable effect of the pincer ligand for the reductive elimination step with the amine, which is followed by C NMR spectroscopy studies.
首次描述了一种镍介导的氨基羰基化反应，利用 NN-钳形镍配合物、烷基锌试剂、化学计量的一氧化碳和胺，可适应后期的碳同位素标记。这项工作扩展了高度成熟的钯促进版本反应的范围，允许碳片段参与三组分反应。最后，得到的结果表明，胺的还原消除步骤中钳形配体具有显著的效果，随后进行了 C NMR 光谱研究。
