串联重复可能为许多三阴性乳腺癌和妇科癌症提供缺失的遗传改变。
Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers.
机构信息
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
出版信息
Cancer Cell. 2018 Aug 13;34(2):179-180. doi: 10.1016/j.ccell.2018.07.011.
In this issue of Cancer Cell, Menghi et al. show that tandem duplications (TDs) are a common genetic feature of gynecological and triple-negative breast cancers. They also provide evidence that these TDs generate genetic alterations driving these cancers, which, if substantiated, will fundamentally change our understanding of their oncogenesis.
在本期《癌细胞》杂志上，Menghi 等人表明串联重复（TDs）是妇科癌症和三阴性乳腺癌的常见遗传特征。他们还提供了证据表明，这些 TD 会产生驱动这些癌症的遗传改变，如果得到证实，将从根本上改变我们对其致癌机制的理解。
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