School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.
Central Laboratory of Longhua Branch, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518109, China.
Eur J Pharm Sci. 2018 Oct 15;123:524-530. doi: 10.1016/j.ejps.2018.08.012. Epub 2018 Aug 11.
The aim of the present work is to evaluate the similarity between PDMS membranes and human skin in vitro in permeation study by linear free energy relationship (LFER) analyses. The values of the permeability coefficient log K (cm/s) under reliable experimental conditions were collected from the literature for a set of 94 compounds including both neutral and ionic species, which cover a broad range of structural diversity. The values of log K (cm/s) have been correlated with Abraham descriptors to yield an equation with R = 0.952 and SD = 0.38 log units. The established LFER model for log K (cm/s) across PDMS membranes showed no close analogy with that through human skin in vitro. A further critical analysis of the coefficients of the LFER models confirmed that the PDMS permeation system is a very poor model for human skin permeation.
本工作旨在通过线性自由能关系 (LFER) 分析评估 PDMS 膜与人体皮肤在体外渗透研究中的相似性。在可靠的实验条件下，从文献中收集了 94 种化合物的渗透系数 log K(cm/s)值，这些化合物包括中性和离子性物质，具有广泛的结构多样性。将 log K(cm/s)值与 Abraham 描述符相关联，得到一个 R=0.952 和 SD=0.38 log 单位的方程。建立的 PDMS 膜透过 log K(cm/s)的 LFER 模型与体外人体皮肤透过的模型没有明显的相似性。对 LFER 模型系数的进一步严格分析证实，PDMS 渗透系统是人体皮肤渗透的一个很差的模型。
