Takenaka T, Okuda M, Kawabori S, Kubo K
Clin Exp Immunol. 1977 Apr;28(1):56-60.
Much peroxidase is released from eosinophils that ingest complexes formed of human immunoglobulins with specific rabbit antibody. The complex formed of IgE with rabbit antibody, was particularly effective. The amount and rate of release of peroxidase was closely related to the amounts of complex ingested by the eosinophils, and degree of lysis of the cell granules. It is proposed that eosinophils attracted to an allergic lesion ingest complexes of IgE, show lysis of granules with release of peroxidase, and that the peroxidase reduces the allergic reaction.
许多过氧化物酶是从摄取了由人免疫球蛋白与特异性兔抗体形成的复合物的嗜酸性粒细胞中释放出来的。由IgE与兔抗体形成的复合物尤其有效。过氧化物酶的释放量和释放速率与嗜酸性粒细胞摄取的复合物量以及细胞颗粒的裂解程度密切相关。有人提出，被吸引到过敏性病变处的嗜酸性粒细胞摄取IgE复合物，显示颗粒裂解并释放过氧化物酶，而过氧化物酶可减轻过敏反应。
