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[肠造口术在肠系膜缺血中的应用]

[The application of intestinal stomas in mesenteric ischemia].

作者信息

Sun S L, Ding W W, Liu B C, Fan X X, Wu X J, Li J S

机构信息

Department of General Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing 210002, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2018 Aug 1;56(8):603-606. doi: 10.3760/cma.j.issn.0529-5815.2018.08.010.

Abstract

To evaluate the application of intestinal stomas in mesenteric ischemia (MI) according to the concept of damage control surgery. Clinical data of 59 MI patients received intestinal stomas at Jinling Hospital, Nanjing University School of Medicine from January 2010 to June 2017 were analyzed retrospectively. There were 41 male and 18 female patients aging of (51±14) years (ranging from 20 to 86 years). All the patients were divided to two groups according to the degree of bowel ischemia: acute MI group (AMI, bowel necrosis, =43) and chronic MI group (CMI, bowel stricture, =16). The medium time from onset to consult of AMI was 7(12) days (()) and the time of CMI was 80(51) days. After the resection of irreversible ischemic intestine, ostomy was carried out for all 59 patients. Patients received oral anticoagulation, enteral nutrition and succus entericus reinfusion therapy for about 6 months after discharge. Then definite surgery to restore digestive tract was preferred. In AMI group, APACHEⅡ score in admission was (16±3). The length of infarcted intestine resected was (160±95) cm, normal bowel left was (220±106) cm. Twelve patients had complications during first post-operation period including sepsis (=8), acute renal failure (=4), acute respiratory distress syndrome (=4), short bowel syndrome (=4). 30-day mortality was 18.6%. Total 30 patients received operation to restore the continuity of intestinal tract after 202(42) days and APACHEⅡ score was 4±2. Two patients suffered from sepsis and were cured after anti-infection. In CMI group, APACHEⅡ score was 16±3 and NRS2002 score was more than 3. The length of infarcted intestine resected was (43±33) cm. All patients had restored the continuity of intestinal tract after 176 (47) days. No major complications occurred during the first and second post-operation period. According to damage control surgery, after early revascularization, patients with acute intestinal necrosis should be treated with infarcted bowel resection and stomas. Besides, second operation to restore the continuity of intestinal tract should be conducted after nutritional support for 6 months. Patients with ischemic enteropathy who cannot be corrected with severe malnutrition should achieve stomas during first operation.

摘要

根据损伤控制外科理念评估肠造口术在肠系膜缺血(MI)中的应用。回顾性分析2010年1月至2017年6月在南京大学医学院附属金陵医院接受肠造口术的59例MI患者的临床资料。患者中男性41例,女性18例,年龄(51±14)岁(范围20至86岁)。所有患者根据肠缺血程度分为两组:急性MI组(AMI,肠坏死,n = 43)和慢性MI组(CMI,肠狭窄,n = 16)。AMI组从发病到就诊的中位时间为7(12)天((范围)),CMI组为80(51)天。对59例患者均行不可逆缺血肠段切除术后行造口术。患者出院后接受口服抗凝、肠内营养及肠液回输治疗约6个月。然后择期行恢复消化道的确定性手术。AMI组入院时APACHEⅡ评分为(16±3)。切除梗死肠段长度为(160±95)cm,剩余正常肠段长度为(220±106)cm。12例患者术后早期出现并发症,包括脓毒症(n = 8)、急性肾衰竭(n = 4)、急性呼吸窘迫综合征(n = 4)、短肠综合征(n = 4)。30天死亡率为18.6%。共30例患者在202(42)天后接受恢复肠道连续性的手术,APACHEⅡ评分为4±2。2例患者发生脓毒症,抗感染治疗后治愈。CMI组APACHEⅡ评分为16±3,NRS2002评分大于3。切除梗死肠段长度为(43±33)cm。所有患者在176(47)天后恢复肠道连续性。术后第一和第二阶段均未发生严重并发症。根据损伤控制外科理念,急性肠坏死患者在早期血管再通后应行梗死肠段切除及造口术。此外,应在营养支持6个月后行恢复肠道连续性的二期手术。对于严重营养不良无法纠正的缺血性肠病患者,应在首次手术时行造口术。

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