Klahr S, Slatopolsky E
Annu Rev Med. 1986;37:71-8. doi: 10.1146/annurev.me.37.020186.000443.
The most significant complication of elevated parathyroid hormone (PTH) levels in uremia is the development of osteitis fibrosa cystica. The hormone also appears to play a role in soft-tissue and organ calcification, metabolic abnormalities (glucose, lipids), and electroencephalographic changes seen in uremic patients. Its role in the hematological abnormalities of uremia (anemia, bleeding) is controversial. A role for PTH in heart and skeletal muscle dysfunction in uremia has not been clearly established. Further studies are required to establish PTH as a "universal" toxin in uremia.
尿毒症患者甲状旁腺激素（PTH）水平升高最显著的并发症是纤维囊性骨炎的发生。该激素似乎还在软组织和器官钙化、代谢异常（葡萄糖、脂质）以及尿毒症患者出现的脑电图变化中起作用。其在尿毒症血液学异常（贫血、出血）中的作用存在争议。PTH在尿毒症心脏和骨骼肌功能障碍中的作用尚未明确确立。需要进一步研究以确定PTH是否为尿毒症中的“通用”毒素。
