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5'-芳基硫属元素-3-氨基胸苷（ACAT）衍生物的合成、抗氧化及抗肿瘤活性

Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.

作者信息

da Rosa Raquel Mello, Piccoli Bruna Candia, da Silva Fernanda D'Avila, Dornelles Luciano, Rocha João B T, Sonego Mariana Souza, Begnini Karine Rech, Collares Tiago, Seixas Fabiana K, Rodrigues Oscar E D

机构信息

LabSelen-NanoBio - Departamento de Química , Universidade Federal de Santa Maria , Santa Maria , Brazil . Email:

Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica , Universidade Federal de Santa Maria , Santa Maria , Brazil.

出版信息

Medchemcomm. 2016 Dec 22;8(2):408-414. doi: 10.1039/c6md00640j. eCollection 2017 Feb 1.

DOI:10.1039/c6md00640j
PMID:30108758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6071852/
Abstract

This article presents the preparation and biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

摘要

本文介绍了新型5'-芳基硫属元素-3-氨基胸苷衍生物作为抗氧化剂（抑制脂质过氧化、清除自由基2,2-二苯基苦味酰基肼并展示类硫醇过氧化物酶活性）以及抗膀胱癌5637药物的制备及其生物活性。硫属元素-氨基胸苷在这两种生物学特性测试中均表现出显著活性，且与硫属元素原子存在直接关系。