Chaturvedi S, Kaul A, Hazari Puja P, Mishra Anil K
Division of Cyclotron and Radiopharmaceutical Sciences , Institute of Nuclear Medicine and Allied Sciences , Brig. S.K. Mazumder Road , Delhi 110054 , India . Email:
Medchemcomm. 2017 Mar 10;8(5):855-870. doi: 10.1039/c6md00610h. eCollection 2017 May 1.
The growing epidemiological and economic burden of neurological diseases on society is tremendous. A correct and timely diagnosis can help in lowering the burden and improving the life quality of both the diseased person and the caretaker. Imaging of the brain (neuroimaging) using CT, MRI, and nuclear imaging methods can provide anatomical and functional information. Neuroreceptors are central to neurotransmission and neuromodulation in the CNS. imaging of receptors in the brain provides powerful tools for the functional study of the central nervous system (CNS) in normal or diseased states. Presently, PET imaging using non-metallic radiotracers dominates the imaging of neuroreceptors. Metal-based probes for SPECT and PET can be economical and logistically easier to use without compromising the information. This review focuses on the development of metallic radiotracers for (Tc) SPECT and (Ga) PET along with future directions based on the metallic probes developed for other imaging modalities namely MRI.
神经疾病对社会造成的流行病学和经济负担日益加重，其规模极为巨大。准确及时的诊断有助于减轻负担，提高患者及其护理人员的生活质量。使用CT、MRI和核成像方法进行脑部成像（神经成像）可提供解剖学和功能信息。神经受体是中枢神经系统（CNS）中神经传递和神经调节的核心。脑部受体成像为正常或患病状态下中枢神经系统（CNS）的功能研究提供了强大工具。目前，使用非金属放射性示踪剂的PET成像在神经受体成像中占据主导地位。用于SPECT和PET的金属基探针在不影响信息的情况下，可能在经济上更实惠且在后勤方面更易于使用。本综述重点关注用于（Tc）SPECT和（Ga）PET的金属放射性示踪剂的发展，以及基于为其他成像模态（即MRI）开发的金属探针的未来发展方向。
