Lewis Andrew J, Jagadeesh Deepa, Mukhopadhyay Sanjay, Budev Marie, Mehta Atul C
Department of Internal Medicine, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.
Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.
Oxf Med Case Reports. 2018 Aug 9;2018(8):omy035. doi: 10.1093/omcr/omy035. eCollection 2018 Aug.
Post-transplant lymphoproliferative disorder (PTLD), a rare but serious complication of solid organ transplantation, is classified into early-onset and late-onset subtypes. Early-onset PTLD occurs a median of 4-11 months after lung transplantation. It rarely presents in the first 2 months post-transplant. Early-onset PTLD usually presents as a solitary pulmonary nodule. We present a unique case of early-onset PTLD that was diagnosed on post-operative Day 35 and presented as a pulmonary parenchymal infiltrate. This case is also exceptional in that the patient had a significant clinical response to only a single dose of rituximab.
移植后淋巴组织增生性疾病（PTLD）是实体器官移植中一种罕见但严重的并发症，分为早发型和晚发型亚型。早发型PTLD在肺移植后中位4 - 11个月发生。在移植后的前2个月很少出现。早发型PTLD通常表现为孤立性肺结节。我们报告一例独特的早发型PTLD病例，该病例在术后第35天被诊断出来，表现为肺实质浸润。该病例的特殊之处还在于患者仅接受单剂量利妥昔单抗就有显著的临床反应。
