Stony Brook University Program in Public Health, Health Sciences Center, Stony Brook University, Level 3, Room 071, Stony Brook, NY, 11794-8338, USA.
Stony Brook University Department of Medicine, Oncology Division, Health Sciences Center, Stony Brook University, 020 Health Sciences Center, Stony Brook, NY, 11794-8160, USA.
Environ Geochem Health. 2019 Apr;41(2):761-768. doi: 10.1007/s10653-018-0170-4. Epub 2018 Aug 14.
The decision whether to fluoridate drinking water continues to be controversial in some communities. Dental and skeletal fluorosis in response to chronic fluoride overexposure are cited as reasons to avoid community water fluoridation in spite of evidence of the oral and skeletal health benefits fluoridation confers. Community fluoridation of ~ 1 mg/L fluoride has not been found to be associated with primary bone cancer but is associated with improved bone strength. No studies have examined fluoride exposure and secondary bone cancer, a common metastasis with significant morbidity. We hypothesize that fluoridation could diminish the likelihood of secondary bone cancer due to its role in bone fortification. We examined the association between community water fluoridation category and prevalence of secondary bone cancer from 2008 to 2010 among cancer patients of 18 years of age or older in counties in New York State. Relative to counties with less than 25% of the water supply fluoridated, we report no association between secondary bone cancer among cancer patients in counties with 25-75% of the water supply fluoridated (β = 0.02, p = 0.96) and among those in counties with > 75% fluoridated (β = 0.02, p = 0.97). We found no evidence of an association between community water fluoridation category and secondary bone cancer from 2008 to 2010 at the county level in New York State.
在一些社区，饮用水氟化的决策仍然存在争议。尽管有证据表明氟化对口腔和骨骼健康有益，但人们还是以慢性氟过量引起的牙齿和骨骼氟中毒为理由，反对社区饮水氟化。目前尚未发现社区氟化浓度约为 1 毫克/升与原发性骨癌有关，但与骨强度的提高有关。没有研究探讨过氟化物暴露与继发性骨癌（一种常见的具有显著发病率的转移癌）之间的关系。我们假设，由于氟化物在骨骼强化方面的作用，氟化可能会降低发生继发性骨癌的可能性。我们研究了 2008 年至 2010 年期间，纽约州各县年龄在 18 岁及以上的癌症患者中，社区水氟化类别与继发性骨癌发病率之间的关系。与供水中氟化物含量低于 25%的县相比，我们报告称，供水中氟化物含量在 25%-75%之间的县（β=0.02，p=0.96）和氟化物含量高于 75%的县（β=0.02，p=0.97）的癌症患者中，继发性骨癌之间没有关联。我们没有发现 2008 年至 2010 年期间，纽约州各县的社区水氟化类别与继发性骨癌之间存在关联的证据。
