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引用本文的文献

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Prescription of sodium valproate to women of childbearing potential in Southern District Mental Health Services in New Zealand.新西兰南部地区精神健康服务中心向育龄妇女开具丙戊酸钠处方。
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2
Are female bipolar patients of reproductive age aware of the teratogenic risk of sodium valproate? A qualitative study.育龄期女性双相情感障碍患者是否知晓丙戊酸钠的致畸风险？一项定性研究。
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本文引用的文献

1
Valproate in the treatment of epilepsy in girls and women of childbearing potential.丙戊酸盐用于治疗有生育潜力的女童和女性的癫痫。
Epilepsia. 2015 Jul;56(7):1006-19. doi: 10.1111/epi.13021. Epub 2015 May 16.
2
Teratogenic risk and contraceptive counselling in psychiatric practice: analysis of anticonvulsant therapy.精神科实践中的致畸风险和避孕咨询：抗癫痫药物治疗的分析。
BMC Psychiatry. 2013 Sep 25;13:234. doi: 10.1186/1471-244X-13-234.
3
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder.心境稳定剂锂和丙戊酸的治疗潜力：不仅仅针对双相障碍。
Pharmacol Rev. 2013 Jan 8;65(1):105-42. doi: 10.1124/pr.111.005512. Print 2013 Jan.
4
Informing patients of the teratogenic potential of mood stabilizing drugs: a case note review of the practice of psychiatrists.向患者告知心境稳定剂的致畸潜力：精神科医生实践的病例记录回顾
J Psychopharmacol. 2007 Nov;21(8):815-9. doi: 10.1177/0269881107077222. Epub 2007 Sep 19.
5
Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma.通过用粒细胞巨噬细胞集落刺激因子或γ干扰素对母体进行免疫刺激，可减少丙戊酸诱导的胎儿畸形。
Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1303-9. doi: 10.1002/ar.a.20397.
6
In utero antiepileptic drug exposure: fetal death and malformations.子宫内抗癫痫药物暴露：胎儿死亡与畸形
Neurology. 2006 Aug 8;67(3):407-12. doi: 10.1212/01.wnl.0000227919.81208.b2.
7
Treatment guidelines for bipolar disorder: a critical review.双相情感障碍治疗指南：一项批判性综述。
J Affect Disord. 2005 May;86(1):1-10. doi: 10.1016/j.jad.2005.01.004.
8
Teratogenicity of sodium valproate.丙戊酸钠的致畸性。
Expert Opin Drug Saf. 2005 Mar;4(2):345-53. doi: 10.1517/14740338.4.2.345.
9
The longer term outcome of children born to mothers with epilepsy.癫痫母亲所生孩子的长期结局。
J Neurol Neurosurg Psychiatry. 2004 Nov;75(11):1575-83. doi: 10.1136/jnnp.2003.029132.
10
Valproate.丙戊酸盐
Bipolar Disord. 2003 Jun;5(3):189-202. doi: 10.1034/j.1399-5618.2003.00031.x.

育龄期女性中丙戊酸盐致畸作用的知晓与记录。

Awareness and documentation of the teratogenic effects of valproate among women of child-bearing potential.

作者信息

Mulryan Deirdre, McIntyre Anna, McDonald Colm, Feeney Sabina, Hallahan Brian

机构信息

Department of Psychiatry,University Hospital Galway,Ireland.

Department of Psychiatry,Roscommon County Hospital,Ireland.

出版信息

BJPsych Bull. 2018 Dec;42(6):233-237. doi: 10.1192/bjb.2018.48. Epub 2018 Aug 15.

DOI:10.1192/bjb.2018.48
PMID:30109830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6465217/
Abstract

Aims and methodWe aimed to evaluate clinical note documentation of valproate prescribing and establish the level of knowledge among women of child-bearing potential regarding valproate-associated adverse effects, including teratogenesis, in a regional Irish mental health service. RESULTS: Of the 42 women prescribed sodium valproate, 21.4% (n = 9) had some documentation in relation to associated risks and 33.3% (n = 14) described an awareness of these risks from consultation with their treating mental health team. On clinical interview, 9.5% (n = 4) of individuals with clear documentation of the risks of teratogenesis described no such awareness. Augmentation with lithium was associated with greater awareness of the teratogenic risks of valproate (P = 0.011).Clinical implicationsA clear description of the teratogenic risks of valproate and potential management strategies, including advice regarding contraception and supplementation with folic acid, should be clearly documented and provided repeatedly and in context to all women of child-bearing age who are prescribed valproate.Declaration of interestNone.

摘要

目的与方法

我们旨在评估丙戊酸盐处方的临床记录，并确定爱尔兰某地区心理健康服务机构中具有生育潜力的女性对丙戊酸盐相关不良反应（包括致畸作用）的了解程度。

结果

在42名开具丙戊酸钠处方的女性中，21.4%（n = 9）有关于相关风险的一些记录，33.3%（n = 14）表示通过与治疗心理健康团队的咨询了解到这些风险。在临床访谈中，有明确致畸风险记录的个体中，9.5%（n = 4）表示没有这种认识。联合使用锂盐与对丙戊酸盐致畸风险的更高认识相关（P = 0.011）。

临床意义

对于所有开具丙戊酸盐处方的育龄女性，应明确记录并反复且结合具体情况提供丙戊酸盐致畸风险的清晰描述以及潜在的管理策略，包括关于避孕和补充叶酸的建议。

利益声明

无。