核因子κB在卵巢肿瘤发病机制中的免疫组织化学分析1。
Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors1.
作者信息
Yilmaz Ercan, Gul Mehmet, Melekoglu Rauf, Koleli Isil
机构信息
Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkey. Manuscript writing.
Full Professor, Department of Histology and Embriyology, Faculty of Medicine, Inonu University, Malatya, Turkey. Histopathological examinations.
出版信息
Acta Cir Bras. 2018 Jul;33(7):641-650. doi: 10.1590/s0102-865020180070000009.
PURPOSE
To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma.
METHODS
NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = ∑ Pi (i+1), where ''Pi'' is the percentage of stained cells in each intensity category (0-100%) and ''i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3).
RESULTS
It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005).
CONCLUSIONS
Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.
目的
研究作为慢性炎症标志物的转录因子核因子κB（NF-κB）在卵巢癌病因学中的作用。
方法
采用免疫组织化学方法进行NF-κB分析。为评估卵巢组织中免疫组织化学NF-κB的表达，采用H评分法。H评分=∑Pi（i+1），其中“Pi”是每个强度类别（0-100%）中染色细胞的百分比，“i”是表示弱染色（i=1）、中度染色（i=2）或强染色（i=3）的强度。
结果
结果显示，浆液性和黏液性腺癌诊断患者组的平均H评分在统计学上显著高于其他两组患者（p<0.005）。
结论
核因子κB是在慢性炎症中起作用的重要介质。通过免疫组织化学方法确定，卵巢癌组的表达率最高。
Zotero 插件