Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food , Hubei University of Technology , Wuhan , Hubei 430068 , People's Republic of China.
Department of Food Science , University of Massachusetts , Amherst , Massachusetts 01003 , United States.
J Agric Food Chem. 2018 Sep 5;66(35):9318-9325. doi: 10.1021/acs.jafc.8b02025. Epub 2018 Aug 27.
Commercial, titanium dioxide (TiO) ingredients used as color additives (E171) in foods and beverages contain an appreciable fraction of particles in the nanoscale range. At present, little information is available regarding the potential impact of food-grade TiO nanoparticles on the gastrointestinal fate of co-ingested bioactives, such as nutraceuticals. In this study, the impact of TiO on the bioaccessibility of β-carotene solubilized in model food emulsions was investigated using a simulated gastrointestinal tract model. Raman spectroscopy showed that there was no charge transfer between β-carotene and TiO but that some β-carotene absorbed to the surface of TiO particles. The initial particle size of the food emulsion did not significantly affect β-carotene bioaccessibility, probably because the same amount of free fatty acids (FFAs) was released by the end of digestion. The addition of TiO at levels typically found in foods also had no significant impact on β-carotene bioaccessibility and FFA release, which suggested that this type of inorganic particle does not interfere with the gastrointestinal fate of these lipophilic bioactive agents. This information is important for ensuring the safety of inorganic nanoparticle utilization within the food industry.
商业用的、作为食品和饮料中着色剂（E171）的二氧化钛（TiO）成分含有相当一部分纳米级颗粒。目前，关于食品级 TiO 纳米颗粒对同时摄入的生物活性物质（如营养保健品）在胃肠道中的命运的潜在影响，信息很少。在这项研究中，使用模拟胃肠道模型研究了 TiO 对模型食品乳液中溶解的β-胡萝卜素生物利用度的影响。拉曼光谱表明，β-胡萝卜素和 TiO 之间没有电荷转移，但一些β-胡萝卜素吸附在 TiO 颗粒表面。食品乳液的初始粒径并没有显著影响β-胡萝卜素的生物利用度，这可能是因为在消化结束时释放出了相同量的游离脂肪酸（FFAs）。在食品中通常发现的 TiO 添加水平也没有对β-胡萝卜素的生物利用度和 FFA 释放产生显著影响，这表明这种类型的无机颗粒不会干扰这些亲脂性生物活性物质在胃肠道中的命运。这些信息对于确保食品工业中无机纳米颗粒的使用安全性非常重要。
