Doherty P C
Immunology. 1977 May;32(5):751-4.
The cell-mediated immune response resulting from infection with lymphocytic choriomeningitis virus (LCMV) was compared in old (18--20 month) and young (4--6 month) random-bred ICR mice. Three separate assay systems were used: the level of virus-specific cytotoxic T-cell activity measured in vitro, time of onset of fatal cell-mediated immunopathology in vivo and adoptive transfer of inflammatory process to immunosuppressed, virus-infected recipients. The capacity of old mice to generate virus-immune effector T cells was, by all of these criteria, greatly diminished. It is suggested that the LCMV-specific T-cell response may prove a useful standard system for determining integrity of immunological surveillance function.
对感染淋巴细胞性脉络丛脑膜炎病毒（LCMV）的老年（18 - 20月龄）和年轻（4 - 6月龄）随机繁殖的ICR小鼠的细胞介导免疫反应进行了比较。使用了三种不同的检测系统：体外测量的病毒特异性细胞毒性T细胞活性水平、体内致死性细胞介导免疫病理学的发病时间以及将炎症过程过继转移给免疫抑制的病毒感染受体。根据所有这些标准，老年小鼠产生病毒免疫效应T细胞的能力大大降低。有人提出，LCMV特异性T细胞反应可能被证明是确定免疫监视功能完整性的一个有用的标准系统。
