Laboratory of Cancer Chemoprevention and Oncopharmacology, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg 197758, Russia; International Research Centre "Biotechnologies of the Third Millennium", ITMO University, St. Petersburg 191002, Russia.
Laboratory of Cancer Chemoprevention and Oncopharmacology, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg 197758, Russia; International Research Centre "Biotechnologies of the Third Millennium", ITMO University, St. Petersburg 191002, Russia.
J Ethnopharmacol. 2018 Dec 5;227:1-7. doi: 10.1016/j.jep.2018.08.013. Epub 2018 Aug 13.
Meadowsweet (Filipendula ulmaria (L.) Maxim.) is a medicinal plant with a variety of therapeutic properties, traditionally used in various diseases including treatment and prevention of tumors. The aim of this study was to present an ethnomedicinal justification that a meadowsweet decoction is able to inhibit colorectal carcinogenesis induced by the methylnitrosourea (MNU) in rats.
The chemical composition of meadowsweet extracts was studied by traditional methods. In animal experiments adult outbred female rats received four intrarectal instillations of MNU, one per week, at dose 4 mg in 0.5 ml saline (the total dose of MNU during the 4-week exposure was 16 mg/rat). After carcinogenic exposure one group (MNU) of rats continued to receive standard feed and tap water throughout life. In another group (MNU+meadowsweet), rats were given daily a decoction of the meadowsweet instead of drinking water and standard feed.
Meadowsweet extracts showed a sufficiently high content of flavonoids and tannins and also some individual phenolic compounds and salicylic acid. In rats after administration of MNU the overall incidence of tumors was 91% with tumor multiplicity of 3.5. The majority of rats (86%) developed multiple tumors of large intestine (most often adenocarcinomas:88 from 107; index of multiplicity - 2.0). In rats from the group MNU+meadowsweet there was a statistically significant decrease of the overall tumor incidence and multiplicity-by 1.4 and 2.9 times, respectively, and the incidence and multiplicity of colon tumors - by 2.0 and 2.8 times, respectively; the incidence and multiplicity of malignant tumors of other localizations was also reduced-by 2.2 and 3.0 times, respectively.
Meadowsweet extract is an effective inhibitor of colorectal carcinogenesis in experiment, that provides support for the traditional use of this plant in the oncology.
绣线菊（Filipendula ulmaria（L.）Maxim.）是一种具有多种治疗特性的药用植物，传统上用于治疗各种疾病，包括肿瘤的治疗和预防。本研究的目的是提供一种民族医学上的理由，即绣线菊煎剂能够抑制甲基亚硝脲（MNU）诱导的大鼠结直肠癌变。
通过传统方法研究绣线菊提取物的化学成分。在动物实验中，成年杂交雌性大鼠每周接受一次直肠内灌胃 MNU，共 4 次，剂量为 4mg/0.5ml 生理盐水（4 周暴露期间大鼠接受的 MNU 总剂量为 16mg/只）。致癌暴露后，一组（MNU）大鼠继续终生接受标准饲料和自来水。在另一组（MNU+绣线菊）中，大鼠每天给予绣线菊煎剂代替饮用水和标准饲料。
绣线菊提取物的黄酮类和单宁含量较高，还含有一些酚类化合物和水杨酸。在 MNU 处理的大鼠中，肿瘤的总发生率为 91%，肿瘤多发性为 3.5。大多数大鼠（86%）患有大肠多发性肿瘤（最常见的是腺癌：107 个中有 88 个；多发性指数为 2.0）。在 MNU+绣线菊组大鼠中，肿瘤总发生率和多发性分别降低了 1.4 倍和 2.9 倍，结肠肿瘤的发生率和多发性分别降低了 2.0 倍和 2.8 倍；其他部位恶性肿瘤的发生率和多发性也分别降低了 2.2 倍和 3.0 倍。
绣线菊提取物是实验性结直肠癌变的有效抑制剂，为该植物在肿瘤学中的传统应用提供了支持。
