• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

羟自由基不参与依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的微粒体脂质过氧化反应。

Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.

作者信息

Bast A, Steeghs M H

出版信息

Experientia. 1986 May 15;42(5):555-6. doi: 10.1007/BF01946700.

DOI:10.1007/BF01946700
PMID:3011492
Abstract

NADPH dependent H2O2 formation in microsomes in the presence of chelated iron leads to formation of hydroxyl radicals. Enhancement of hydroxyl radical generation (via ferric-EDTA or sodium azide) did not result in a concomitant increase in lipid peroxidation; rather, a decrease was observed. Moreover, the hydroxyl radical scavenger DMSO did not inhibit lipid peroxidation. This comparison of hydroxyl radical formation with lipid peroxidation suggests that hydroxyl radicals do not play a part in NADPH-dependent lipid peroxidation.

摘要

在存在螯合铁的情况下，微粒体中NADPH依赖性过氧化氢的形成会导致羟基自由基的形成。（通过铁-乙二胺四乙酸或叠氮化钠）增强羟基自由基的生成并未导致脂质过氧化的相应增加；相反，观察到的是减少。此外，羟基自由基清除剂二甲基亚砜并未抑制脂质过氧化。这种羟基自由基形成与脂质过氧化的比较表明，羟基自由基在NADPH依赖性脂质过氧化中不起作用。

相似文献

1
Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.羟自由基不参与依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的微粒体脂质过氧化反应。
Experientia. 1986 May 15;42(5):555-6. doi: 10.1007/BF01946700.
2
Comparison of the ability of ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation, and hydroxyl radical generation.三价铁配合物催化微粒体化学发光、脂质过氧化和羟基自由基生成能力的比较。
Arch Biochem Biophys. 1988 Aug 1;264(2):482-91. doi: 10.1016/0003-9861(88)90313-x.
3
Role of catalase and hydroxyl radicals in the oxidation of methanol by rat liver microsomes.过氧化氢酶和羟自由基在大鼠肝脏微粒体氧化甲醇中的作用。
Biochem Pharmacol. 1982 Feb 1;31(3):329-35. doi: 10.1016/0006-2952(82)90179-4.
4
Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine.铁螯合剂去铁胺对醇类微粒体氧化及羟自由基清除剂的抑制作用。
Biochem J. 1983 Jan 15;210(1):107-13. doi: 10.1042/bj2100107.
5
The effect of chronic alcohol feeding on lipid peroxidation in microsomes: lack of relationship to hydroxyl radical generation.
Biochem Biophys Res Commun. 1984 Jan 13;118(1):233-8. doi: 10.1016/0006-291x(84)91091-x.
6
NADH-dependent generation of reactive oxygen species by microsomes in the presence of iron and redox cycling agents.在铁和氧化还原循环剂存在的情况下，微粒体通过依赖烟酰胺腺嘌呤二核苷酸（NADH）产生活性氧。
Biochem Pharmacol. 1991 Jul 15;42(3):529-35. doi: 10.1016/0006-2952(91)90315-v.
7
NADPH- and linoleic acid hydroperoxide-induced lipid peroxidation and destruction of cytochrome P-450 in hepatic microsomes.烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和亚油酸氢过氧化物诱导肝微粒体中的脂质过氧化及细胞色素P - 450破坏。
Biochem Pharmacol. 1987 May 1;36(9):1447-55. doi: 10.1016/0006-2952(87)90109-2.
8
NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates.烟酰胺腺嘌呤二核苷酸（NADH）依赖的微粒体与铁复合物的相互作用及活性氧中间体的产生。
Arch Biochem Biophys. 1989 Dec;275(2):540-50. doi: 10.1016/0003-9861(89)90400-1.
9
Interactions between paraquat and ferric complexes in the microsomal generation of oxygen radicals.百草枯与铁复合物在微粒体中产生氧自由基过程中的相互作用。
Biochem Pharmacol. 1989 Sep 1;38(17):2911-8. doi: 10.1016/0006-2952(89)90449-8.
10
Generation of hydroxyl radicals during the enzymatic reductions of the Fe3+-ADP-phosphate-adriamycin and Fe3+-ADP-EDTA systems. Less involvement of hydroxyl radical and a great importance of proposed perferryl ion complexes in lipid peroxidation.在Fe3+-ADP-磷酸-阿霉素和Fe3+-ADP-乙二胺四乙酸体系的酶促还原过程中羟基自由基的产生。羟基自由基参与较少，而所提出的过氧铁离子络合物在脂质过氧化中具有重要作用。
Biochim Biophys Acta. 1983 Oct 11;753(3):411-21. doi: 10.1016/0005-2760(83)90065-6.

引用本文的文献

1
Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals.氧浓度对乙醇微粒体氧化及氧自由基生成的影响。
Biochem J. 1988 May 1;251(3):787-94. doi: 10.1042/bj2510787.
2
Free radicals and oxygen toxicity.自由基与氧毒性。
Pharm Res. 1988 May;5(5):253-60. doi: 10.1023/a:1015914418014.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.通过汉茨希反应对比色法测定甲醛。
Biochem J. 1953 Oct;55(3):416-21. doi: 10.1042/bj0550416.
3
Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor.微粒体谷胱甘肽依赖性不稳定因子对脂质过氧化的保护作用。
FEBS Lett. 1983 Aug 8;159(1-2):24-8. doi: 10.1016/0014-5793(83)80409-8.
4
Cytochrome P450 oxidase activity and its role in NADPH dependent lipid peroxidation.
FEBS Lett. 1983 Jan 24;151(2):185-8. doi: 10.1016/0014-5793(83)80065-9.
5
Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation.过氧化氢对微粒体脂质过氧化起始的影响。
Biochem Pharmacol. 1983 Jan 1;32(1):123-7. doi: 10.1016/0006-2952(83)90663-9.
6
Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.乙醇诱导型及兔肝微粒体细胞色素P-450其他形式催化乙醇氧化及羟自由基形成的机制
J Biol Chem. 1984 May 25;259(10):6447-58.
7
Adriamycin-iron catalysed phospholipid peroxidation: a reaction not involving reduced adriamycin or hydroxyl radicals.阿霉素-铁催化的磷脂过氧化：一种不涉及还原型阿霉素或羟基自由基的反应。
Biochem Pharmacol. 1983 Jun 15;32(12):1949-52. doi: 10.1016/0006-2952(83)90065-5.
8
On the significance of the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism.关于细胞色素P-450依赖性羟基自由基介导的氧化机制的意义
Xenobiotica. 1982 Nov;12(11):673-86. doi: 10.3109/00498258209038943.
9
The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts.超氧化物和羟基自由基在铁盐催化的磷脂过氧化反应中的作用。
FEBS Lett. 1982 Dec 27;150(2):454-8. doi: 10.1016/0014-5793(82)80788-6.
10
Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems.由羟基自由基生成系统在二甲基亚砜代谢过程中产生甲醛。
Biochemistry. 1981 Oct 13;20(21):6006-12. doi: 10.1021/bi00524a013.