Paediatric Department, Larnaca General Hospital, Inomenon Polition, Larnaca 6042, Cyprus; European University Medical School, 6, Diogenis Street, Engomi, 1516 Nicosia, Cyprus.
Paediatric Department, Larnaca General Hospital, Inomenon Polition, Larnaca 6042, Cyprus.
Vaccine. 2018 Sep 11;36(38):5685-5691. doi: 10.1016/j.vaccine.2018.08.021. Epub 2018 Aug 14.
Pneumococcus is a common cause of invasive and non-invasive infections in children. In areas with high vaccination coverage, universal infant vaccination with conjugated pneumococcal vaccine (PCV) has significantly decreased the incidence of vaccine type nasopharyngeal carriage and invasive pneumococcal disease. The aim of this study is to examine immunization coverage rate and timely administration of the recently introduced PCV and compare to the established diphtheria-tetanus-acellular pertussis vaccine (DTaP) with similar schedule.
A stratified random sample of healthy infants and children 6-36 months of age were recruited. Demographic data were collected from parents. Among enrolled children, immunization status for DTaP and PCV was noted from the child's health booklet.
Of 1105 children enrolled in the study, 586 (53%) were vaccinated in the private sector and the rest in the public sector. A significant higher proportion of children vaccinated at the private sector were fully vaccinated for PCV (71% versus 58%, p < 0.05) while no difference in the DTaP coverage was observed. Conversely, the compliance to the recommended vaccination schedule was much higher in the public sector for the first and second dose of PCV and second dose of DTaP. The overall, timely administration was higher for the DTaP vaccine when compared to PCV (p < 0.05). Moreover, adherence to the program was higher for the firstborn child of the family while significant differences were observed between different geographic regions. Interestingly, co-administration of DTaP and PCV was observed in only 2% of the children.
In children residing in Cyprus, vaccination coverage and adherence to PCV vaccination schedule are significantly lower compared to the established DTaP vaccine. There is an urgent need for increasing the overall vaccination coverage as well as improving the adherence to vaccination schedule. Possible interventions are proposed.
肺炎球菌是导致儿童侵袭性和非侵袭性感染的常见病原体。在疫苗接种覆盖率高的地区，对婴儿普遍接种结合型肺炎球菌疫苗（PCV）显著降低了疫苗型鼻咽携带和侵袭性肺炎球菌病的发生率。本研究旨在检查最近引入的 PCV 的免疫接种覆盖率和及时接种情况，并与具有类似时间表的已建立的白喉-破伤风-无细胞百日咳疫苗（DTaP）进行比较。
对 6-36 月龄的健康婴儿和儿童进行分层随机抽样。从父母那里收集人口统计学数据。在登记的儿童中，从儿童健康手册中记录 DTaP 和 PCV 的免疫状况。
在 1105 名入组研究的儿童中，586 名（53%）在私营部门接种疫苗，其余在公共部门接种疫苗。在私营部门接种疫苗的儿童中，完全接种 PCV 的比例显著更高（71%比 58%，p<0.05），而 DTaP 的覆盖率没有差异。相反，在公共部门，PCV 的第一和第二剂以及 DTaP 的第二剂接种的推荐接种时间表的合规性要高得多。总体而言，与 PCV 相比，DTaP 疫苗的及时接种率更高（p<0.05）。此外，家庭中第一个孩子的依从性更高，不同地理区域之间存在显著差异。有趣的是，仅观察到 2%的儿童同时接种 DTaP 和 PCV。
在塞浦路斯居住的儿童中，PCV 的接种覆盖率和对 PCV 接种时间表的依从性明显低于已建立的 DTaP 疫苗。迫切需要提高总体疫苗接种覆盖率，并改善对疫苗接种时间表的依从性。提出了可能的干预措施。
