99m锝骨扫描剂——II. 99m锝（锡）焦磷酸盐络合物在骨矿物相上的吸附

99mTc bone scanning agents--II. Adsorption of 99mTc(Sn)pyrophosphate complexes on the mineral phase of bone.

作者信息

Kroesbergen J, van Steijn A M, Gelsema W J, de Ligny C L

出版信息

Int J Nucl Med Biol. 1986;12(6):411-7. doi: 10.1016/s0047-0740(86)80001-8.

Abstract

The adsorption of pyrophosphate, tin-pyrophosphate and 99mTc(Sn)pyrophosphate on Ca3(PO4)2 was investigated at pH 4.0 and pH 7.4. All components were radioactively labeled. Tin and reduced technetium were in most cases almost completely bound. The adsorption of pyrophosphate, tin(II) and technetium-99m at pH 4.0 was higher than at pH 7.4. The presence of tin gave rise to an increase of the pyrophosphate adsorption that was much larger than can be accounted for by a stoichiometric adsorption of tin-pyrophosphate. It is concluded that tin and technetium are bound as negatively charged complexes with pyrophosphate. Finally it is argued that the fraction of the bone scanning agent that reaches the bone surface is adsorbed completely by the mineral phase.

摘要

在pH值为4.0和7.4的条件下，研究了焦磷酸盐、焦磷酸锡和99mTc（Sn）焦磷酸盐在Ca3(PO4)2上的吸附情况。所有成分均用放射性标记。在大多数情况下，锡和还原态锝几乎完全结合。在pH值为4.0时，焦磷酸盐、锡（II）和99m锝的吸附量高于pH值为7.4时。锡的存在导致焦磷酸盐吸附量增加，其增加量远大于焦磷酸锡化学计量吸附所能解释的量。得出的结论是，锡和锝以带负电荷的络合物形式与焦磷酸盐结合。最后有人认为，到达骨表面的骨扫描剂部分被矿相完全吸附。