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camR, a negative regulator locus of the cytochrome P-450cam hydroxylase operon.camR，细胞色素P-450cam羟化酶操纵子的一个负调控基因座。
J Bacteriol. 1986 Jun;166(3):1089-95. doi: 10.1128/jb.166.3.1089-1095.1986.
2
Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida.恶臭假单胞菌细胞色素P-450cam羟化酶中涉及的NADH-假单胞菌素还原酶基因（camA）和假单胞菌素基因（camB）的克隆及核苷酸序列
J Biochem. 1989 Nov;106(5):831-6. doi: 10.1093/oxfordjournals.jbchem.a122939.
3
Evidence for autoregulation of camR, which encodes a repressor for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.camR自我调控的证据，camR编码恶臭假单胞菌CAM质粒上细胞色素P-450cam羟化酶操纵子的阻遏物。
J Bacteriol. 1993 Dec;175(24):7828-33. doi: 10.1128/jb.175.24.7828-7833.1993.
4
Nucleotide sequence of the Pseudomonas putida cytochrome P-450cam gene and its expression in Escherichia coli.恶臭假单胞菌细胞色素P-450cam基因的核苷酸序列及其在大肠杆菌中的表达。
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5
Nucleotide sequence of the gene encoding a repressor for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.
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Purification and characterization of a cam repressor (CamR) for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.恶臭假单胞菌CAM质粒上细胞色素P-450cam羟化酶操纵子的Cam阻遏物（CamR）的纯化与特性分析
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Transcription of the cam operon and camR genes in Pseudomonas putida PpG1.恶臭假单胞菌PpG1中cam操纵子和camR基因的转录
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6
Evidence for autoregulation of camR, which encodes a repressor for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.camR自我调控的证据，camR编码恶臭假单胞菌CAM质粒上细胞色素P-450cam羟化酶操纵子的阻遏物。
J Bacteriol. 1993 Dec;175(24):7828-33. doi: 10.1128/jb.175.24.7828-7833.1993.
7
Purification and characterization of a cam repressor (CamR) for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid.恶臭假单胞菌CAM质粒上细胞色素P-450cam羟化酶操纵子的Cam阻遏物（CamR）的纯化与特性分析
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8
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Transcription of the cam operon and camR genes in Pseudomonas putida PpG1.恶臭假单胞菌PpG1中cam操纵子和camR基因的转录
J Bacteriol. 1993 Nov;175(21):6953-8. doi: 10.1128/jb.175.21.6953-6958.1993.
10
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J Bacteriol. 1988 Apr;170(4):1548-53. doi: 10.1128/jb.170.4.1548-1553.1988.

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
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Enzymic synthesis of juvenile hormone in locust corpora allata: evidence for a microsomal cytochrome P-450 linked methyl farnesoate epoxidase.蝗虫咽侧体中保幼激素的酶促合成：微粒体细胞色素P-450相关法尼酸甲酯环氧化酶的证据。
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Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.恶臭假单胞菌细胞色素P-450的氨基酸序列。II. 溴化氰肽段、酸裂解肽段及完整序列。
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Molecular and functional analysis of the TOL plasmid pWWO from Pseudomonas putida and cloning of genes for the entire regulated aromatic ring meta cleavage pathway.恶臭假单胞菌TOL质粒pWWO的分子与功能分析及整个调控型芳香环间位裂解途径基因的克隆
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10
Construction of a partial diploid for the degradative pathway encoded by the TOL plasmid (pWWO) from Pseudomonas putida mt-2: evidence for the positive nature of the regulation by the xyIR gene.构建恶臭假单胞菌mt-2的TOL质粒（pWWO）编码的降解途径的部分二倍体：xyIR基因正向调控性质的证据。
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camR，细胞色素P-450cam羟化酶操纵子的一个负调控基因座。

camR, a negative regulator locus of the cytochrome P-450cam hydroxylase operon.

作者信息

Koga H, Aramaki H, Yamaguchi E, Takeuchi K, Horiuchi T, Gunsalus I C

出版信息

J Bacteriol. 1986 Jun;166(3):1089-95. doi: 10.1128/jb.166.3.1089-1095.1986.

DOI:10.1128/jb.166.3.1089-1095.1986
PMID:3011733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC215236/
Abstract

A 4.27-kilobase insert from a HindIII DNA library of Pseudomonas putida carrying the CAM plasmid allowed coordinate expression of genes camD and camC under control of camR, an upstream regulator. The camC gene specifies cytochrome P-450cam, and camD specifies the 5-exo-alcohol dehydrogenase. A 1.38-kilobase deletion from the insert results in the constitutive expression of genes camC and camD; transformation in trans restores the substrate control, indicating that camR is a negative regulator.

摘要

携带CAM质粒的恶臭假单胞菌HindIII DNA文库中的一个4.27千碱基插入片段，使得camD和camC基因在camR（一种上游调节因子）的控制下能够协同表达。camC基因编码细胞色素P-450cam，camD基因编码5-外向醇脱氢酶。该插入片段缺失1.38千碱基会导致camC和camD基因组成型表达；反式转化可恢复底物控制，这表明camR是一种负调节因子。